Matt Harmon

174 Chapter eight Supplemental Table 3. Sensitivity analysis of PaCO 2 groups including all patients (n=939), adjusted for confounders. Analysis OR CI P-value Hypercapnia vs normocapnia 0.70 0.30-1.64 0.41 Hypercapnia vs non-hypercapnia 0.73 0.48-1.12 0.15 Hypocapnia vs normocapnia 1.04 0.41-2.60 0.94 Hypocapnia vs non-hypocapnia 0.99 0.70-1.41 0.96 PaCO 2 -AUC first four measurements 1.03 0.86-1.24 0.71 PaCO 2 -AUC all measurements 1.09 0.89-1.34 0.40 Amplitude 1.00 0.88-1.13 0.98 OR = Odds Ratio. CI = Confidence Interval. PaCO 2  = partial arterial carbon dioxide pressure. AUC = Area under curve. OR < 1 indicates better outcome. Patients with no outcome data (n=6), no PaCO 2 data (n=2) and lack of confounders (n=5) were excluded, 926 patients we included in the final analysis. Confounders corrected for: age (years), sex (male/female), chronic heart failure (yes/no), asthma/ chronic obstructive pulmonary disease (yes/no), cardiac arrest witnessed (yes/no), bystander CPR (yes/ no), first rhythm shockable (yes/no), time to ROSC (minutes), GCS-Motor Score (1 versus 2 - 5), shock on admission (yes/no), pH at admission (units). Supplemental Table 4. Sensitivity analysis of PaCO 2 groups including complete cases (n=485), adjusted for confounders. Analysis OR CI P-value Hypercapnia vs normocapnia 0.60 0.21 – 1.68 0.33 Hypercapnia vs non-hypercapnia 0.76 0.44 – 1.30 0.32 Hypocapnia vs normocapnia 1.21 0.41 – 3.56 0.73 Hypocapnia vs non-hypocapnia 1.19 0.76 – 1.87 0.45 PaCO 2 -AUC first four measurements 0.97 0.74 – 1.27 0.84 PaCO 2 -AUC all measurements 1.00 0.71 – 1.43 0.96 Amplitude 1.06 0.89 – 1.24 0.52 OR = Odds Ratio. CI = Confidence Interval. PaCO 2  = partial arterial carbon dioxide pressure. AUC = Area under curve. OR < 1 indicates better outcome. Confounders corrected for: age (years), sex (male/female), chronic heart failure (yes/no), asthma/chronic obstructive pulmonary disease (yes/no), cardiac arrest witnessed (yes/no), bystander CPR (yes/no), first rhythm shockable (yes/no), time to ROSC (minutes), GCS-Motor Score (1 versus 2 - 5), shock on admission (yes/no), pH at admission (units).