Matt Harmon

185 Chapter nine Table 3. Association between antibiotic prophylaxis and pneumonia (both confirmed and suspected) in the first 14 days of ICU admission, adjusted for confounders. aOR 95% CI P-value Prophylaxis 0.59 0.43 - 0.79 0.0005 Prophylaxis + age 0.57 0.42 - 0.78 0.0003 Prophylaxis + age + SOFA 0.64 0.46 - 0.89 0.009 Prophylaxis + age + SOFA + asthma/COPD 0.65 0.46 - 0.90 0.01 Prophylaxis + age + SOFA + asthma/COPD + time to ROSC 0.64 0.46 - 0.90 0.009 Prophylaxis + age + SOFA + asthma/COPD + time to ROSC + immunosuppression 0.64 0.46 - 0.90 0.01 Prophylaxis + age + SOFA + clustering within centers 0.55 0.20 - 1.47 0.22 Abbreviations: CI, confidence interval. COPD, chronic obstructive pulmonary disease. aOR, adjusted odds ratio. SOFA, sequential organ failure assessment. ROSC, return of spontaneous circulation. Figure 3 . Pathogen distribution in sputum cultures in confirmed pneumonia and bacteremia cases in the first 14 days of ICU-admission, according to different target temperatures. GNC, Gram negative culture, GPC, Gram positive culture, PMF, polymicrobial flora, TTM, target temperature management.