Matt Harmon

189 Chapter nine References 1 Perbet, S. et al. Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. American journal of respiratory and critical care medicine 184 , 1048-1054, doi:10.1164/ rccm.201102-0331OC (2011). 2 Mongardon, N. et al. Infectious complications in out-of-hospital cardiac arrest patients in the therapeutic hypothermia era. Crit Care Med 39 , 1359-1364, doi:10.1097/CCM.0b013e3182120b56 (2011). 3 Gajic, O., Festic, E. & Afessa, B. Infectious complications in survivors of cardiac arrest admitted to the medical intensive care unit. Resuscitation 60 , 65-69, doi:10.1016/j.resuscitation.2003.08.005 (2004). 4 Tsai, M. S. et al. Infections in the survivors of out-of-hospital cardiac arrest in the first 7 days. Intensive care medicine 31 , 621-626, doi:10.1007/s00134-005-2612-6 (2005). 5 Dankiewicz, J. et al. Infectious complications after out-of-hospital cardiac arrest-A comparison between two target temperatures. Resuscitation 113 , 70-76, doi:10.1016/j.resuscitation.2016.12.008 (2017). 6 Beurskens, C. J. et al. Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia. Critical care 18 , R162, doi:10.1186/cc14002 (2014). 7 Kakavas, S., Mongardon, N., Cariou, A., Gulati, A. & Xanthos, T. Early-onset pneumonia after out- of-hospital cardiac arrest. The Journal of infection 70 , 553-562, doi:10.1016/j.jinf.2015.01.012 (2015). 8 Davies, K. J., Walters, J. H., Kerslake, I. M., Greenwood, R. & Thomas, M. J. Early antibiotics improve survival following out-of hospital cardiac arrest. Resuscitation 84 , 616-619, doi:10.1016/j. resuscitation.2012.11.004 (2013). 9 Newell, C. & Thomas, M. Prophylactic antibiotic therapy for all out-of-hospital cardiac arrest survivors? Resuscitation 92 , A4-A5 (2015). 10 Hellenkamp, K. et al. Early pneumonia and timing of antibiotic therapy in patients after nontraumatic out-of-hospital cardiac arrest. Critical care 20 , 31, doi:10.1186/s13054-016-1191-y (2016). 11 Gagnon, D. J. et al. Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management. Resuscitation 92 , 154-159, doi:10.1016/j.resuscitation.2015.01.035 (2015). 12 Nielsen, N. et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. The New England journal of medicine 369 , 2197-2206, doi:10.1056/NEJMoa1310519 (2013). 13 Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. American journal of respiratory and critical care medicine 171 , 388-416, doi:10.1164/rccm.200405-644ST (2005). 14 Nielsen, N. et al. Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia. Crit Care Med 39 , 57-64, doi:10.1097/CCM.0b013e3181fa4301 (2011). 15 Michelet, P. et al. Early onset pneumonia in severe chest trauma: a risk factor analysis. The Journal of trauma 68 , 395-400, doi:10.1097/TA.0b013e3181a601cb (2010). 16 Hyllienmark, P. et al. High incidence of post-injury pneumonia in intensive care-treated trauma patients. Acta anaesthesiologica Scandinavica 57 , 848-854, doi:10.1111/aas.12111 (2013). 17 Bronchard, R. et al. Early onset pneumonia: risk factors and consequences in head trauma patients. Anesthesiolog y 100 , 234-239 (2004). 18 Boddie, D. E., Currie, D. G., Eremin, O. & Heys, S. D. Immune suppression and isolated severe head injury: a significant clinical problem. British journal of neurosurgery 17 , 405-417 (2003). 19 Hazeldine, J. et al. Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study. PLoS medicine 14 , e1002338, doi:10.1371/journal.pmed.1002338 (2017).