Matt Harmon

207 Summary References 1 Romanovsky, A. A. & Szekely, M. Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation. Med Hypotheses 50 , 219-226 (1998). 2 Fonseca, M. T. et al. Spontaneous hypothermia in human sepsis is a transient, self-limiting and non- terminal response. Journal of applied physiolog y , jap 00004 02016, doi:10.1152/japplphysiol.00004.2016 (2016). 3 Almeida, M. C., Steiner, A. A., Branco, L. G. & Romanovsky, A. A. Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation. Eur J Neurosci 23 , 3359-3367, doi:10.1111/j.1460- 9568.2006.04854.x (2006). 4 Young, P. J. & Bellomo, R. Fever in sepsis: is it cool to be hot? Critical care 18 , 109, doi:10.1186/cc13726 (2014). 5 Steiner, A. A., Fonseca, M. T. & Soriano, F. G. Should we assume that hypothermia is a dysfunction in sepsis? Critical care 21 , 8, doi:10.1186/s13054-016-1584-y (2017). 6 Corrigan, J. J., Fonseca, M. T., Flatow, E. A., Lewis, K. & Steiner, A. A. Hypometabolism and hypothermia in the rat model of endotoxic shock: independence of circulatory hypoxia. J Physiol 592 , 3901-3916, doi:10.1113/jphysiol.2014.277277 (2014). 7 Gargaglioni, L. H., Steiner, A. A. & Branco, L. G. Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia. Brain Res 1044 , 16-24, doi:10.1016/j. brainres.2005.02.069 (2005). 8 Hodges, M. R. et al. Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 , 2495-2505, doi:10.1523/JNEUROSCI.4729-07.2008 (2008). 9 Drewry, A. M., Fuller, B. M., Skrupky, L. P. & Hotchkiss, R. S. The Presence of Hypothermia Within 24 Hours of Sepsis Diagnosis Predicts Persistent Lymphopenia. Crit Care Med , doi:10.1097/ CCM.0000000000000940 (2015). 10 Leon, K., Moisan, C., Amerand, A., Poupon, G. & L’Her, E. Effect of induced mild hypothermia on two pro-inflammatory cytokines and oxidative parameters during experimental acute sepsis. Redox Rep 18 , 120-126, doi:10.1179/1351000213Y.0000000049 (2013). 11 Beurskens, C. J. P. et al. Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover. Crit Care Med 40 , 919-926, doi:Doi 10.1097/Ccm.0b013e3182373174 (2012). 12 Itenov, T. S. et al. Induced hypothermia in patients with septic shock and respiratory failure (CASS): a randomised, controlled, open-label trial. Lancet Respir Med 6 , 183-192, doi:10.1016/S2213- 2600(18)30004-3 (2018). 13 Yang, Y. L. et al. Body temperature control in patients with refractory septic shock: too much may be harmful. Chin Med J (Engl) 126 , 1809-1813 (2013). 14 Gao, Y. et al. Effects of Target Temperature Management on the Outcome of Septic Patients with Fever. BioMed research international 2017 , 3906032, doi:10.1155/2017/3906032 (2017). 15 Zeiner, A. et al. Hyperthermia After Cardiac Arrest Is Associated With an Unfavorable Neurologic Outcome. Archives of Internal Medicine 161 , 2007-2012, doi:10.1001/archinte.161.16.2007 (2001). 16 Nielsen, N. et al. Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia. Crit Care Med 39 , 57-64, doi:10.1097/CCM.0b013e3181fa4301 (2011). 17 Nuckton , T. J. et al. Pulmonary Dead-Space Fraction as a Risk Factor for Death in the Acute Respiratory Distress Syndrome. New England Journal of Medicine 346 , 1281-1286, doi:10.1056/ NEJMoa012835 (2002).