Matt Harmon

208 Chapter ten 18 Jakkula, P. et al. Targeting two different levels of both arterial carbon dioxide and arterial oxygen after cardiac arrest and resuscitation: a randomised pilot trial. Intensive care medicine 44 , 2112-2121, doi:10.1007/s00134-018-5453-9 (2018). 19 Eastwood, G. M. et al. Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial). Resuscitation 104 , 83-90, doi:10.1016/j. resuscitation.2016.03.023 (2016). 20 Wang, H. E. et al. Post-resuscitation arterial oxygen and carbon dioxide and outcomes after out-of- hospital cardiac arrest. Resuscitation 120 , 113-118, doi:10.1016/j.resuscitation.2017.08.244 (2017). 21 Roberts, B. W. et al. Association between postresuscitation partial pressure of arterial carbon dioxide and neurological outcome in patients with post-cardiac arrest syndrome. Circulation 127 , 2107-2113, doi:10.1161/circulationaha.112.000168 (2013). 22 Vaahersalo, J. et al. Arterial blood gas tensions after resuscitation from out-of-hospital cardiac arrest: associations with long-term neurologic outcome. Crit Care Med 42 , 1463-1470, doi:10.1097/ CCM.0000000000000228 (2014). 23 Hope Kilgannon, J. et al. Partial pressure of arterial carbon dioxide after resuscitation from cardiac arrest and neurological outcome: A prospective multi-center protocol-directed cohort study. Resuscitation 135 , 212-220, doi:10.1016/j.resuscitation.2018.11.015 (2019). 24 Eastwood, G. M. & Nichol, A. Optimal ventilator settings after return of spontaneous circulation. Curr Opin Crit Care 26 , 251-258, doi:10.1097/MCC.0000000000000720 (2020). 25 Perbet, S. et al. Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. American journal of respiratory and critical care medicine 184 , 1048-1054, doi:10.1164/ rccm.201102-0331OC (2011). 26 Francois, B. et al. Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest. The New England journal of medicine 381 , 1831-1842, doi:10.1056/NEJMoa1812379 (2019). 27 Cassini, A. et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. The Lancet. Infectious diseases 19 , 56-66, doi:10.1016/S1473-3099(18)30605-4 (2019). 28 Martin-Loeches, I. Current Concepts in Community and Ventilator Associated Lower Respiratory Tract Infections in ICU Patients. Antibiotics (Basel) 9 , doi:10.3390/antibiotics9070380 (2020). 29 Taccone, F. S., Picetti, E. & Vincent, J. L. High Quality Targeted Temperature Management (TTM) After Cardiac Arrest. Critical care 24 , 6, doi:10.1186/s13054-019-2721-1 (2020). 30 Lascarrou, J. B. et al. Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. The New England journal of medicine 381 , 2327-2337, doi:10.1056/NEJMoa1906661 (2019). 31 Geocadin, R. G. Moving Beyond One-Size-Fits-All Treatment for Patients After Cardiac Arrest. JAMA Netw Open 3 , e208809, doi:10.1001/jamanetworkopen.2020.8809 (2020). 32 Admiraal, M. M. et al. Electroencephalographic reactivity as predictor of neurological outcome in postanoxic coma: A multicenter prospective cohort study. Ann Neurol 86 , 17-27, doi:10.1002/ ana.25507 (2019). 33 Callaway, C. W. et al. Association of Initial Illness Severity and Outcomes After Cardiac Arrest With Targeted Temperature Management at 36 degrees C or 33 degrees C. JAMA Netw Open 3 , e208215, doi:10.1001/jamanetworkopen.2020.8215 (2020). 34 Scicluna, B. P. et al. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med 5 , 816-826, doi:10.1016/s2213-2600(17)30294-1 (2017). 35 DiPasquale, D. M., Kolkhorst, F. W. & Buono, M. J. Acute normobaric hypoxia reduces body temperature in humans. High Alt Med Biol 16 , 61-66, doi:10.1089/ham.2014.1098 (2015). 36 Harms, F., Stolker, R. J. & Mik, E. Cutaneous Respirometry as Novel Technique to Monitor Mitochondrial Function: A Feasibility Study in Healthy Volunteers. PloS one 11 , e0159544, doi:10.1371/ journal.pone.0159544 (2016).