Matt Harmon

22 Chapter one 19 Baena, R. C., Busto, R., Dietrich, W. D., Globus, M. Y. & Ginsberg, M. D. Hyperthermia delayed by 24 hours aggravates neuronal damage in rat hippocampus following global ischemia. Neurolog y 48 , 768-773, doi:10.1212/wnl.48.3.768 (1997). 20 Schumacker, P. T., Rowland, J., Saltz, S., Nelson, D. P. & Wood, L. D. Effects of hyperthermia and hypothermia on oxygen extraction by tissues during hypovolemia. Journal of applied physiolog y 63 , 1246-1252 (1987). 21 Satoh, T., Nakasone, S. & Nishimoto, A. Cerebral blood flow response to the tissue temperature in tumour and brain tissues. Int J Hyperthermia 5 , 683-696, doi:10.3109/02656738909140493 (1989). 22 Hasday, J. D., Fairchild, K. D. & Shanholtz, C. The role of fever in the infected host. Microbes and infection / Institut Pasteur 2 , 1891-1904 (2000). 23 Tulapurkar, M. E. et al. Febrile-range hyperthermia modifies endothelial and neutrophilic functions to promote extravasation. American journal of respiratory cell and molecular biolog y 46 , 807-814 (2012). 24 Clemmer, T. P. et al. Hypothermia in the sepsis syndrome and clinical outcome. The Methylprednisolone Severe Sepsis Study Group. Crit Care Med 20 , 1395-1401 (1992). 25 Blair, E., Henning, G., Hornick, R. & Cowley, R. A. Hypothermia in Bacteremic Shock. Arch Surg 89 , 619-629 (1964). 26 Arons, M. M. et al. Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med 27 , 699-707 (1999). 27 Romanovsky, A. A. & Szekely, M. Fever and hypothermia: two adaptive thermoregulatory responses to systemic inflammation. Med Hypotheses 50 , 219-226 (1998). 28 Fonseca, M. T. et al. Spontaneous hypothermia in human sepsis is a transient, self-limiting and non- terminal response. Journal of applied physiolog y , jap 00004 02016, doi:10.1152/japplphysiol.00004.2016 (2016). 29 Almeida, M. C., Steiner, A. A., Branco, L. G. & Romanovsky, A. A. Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation. Eur J Neurosci 23 , 3359-3367, doi:10.1111/j.1460- 9568.2006.04854.x (2006). 30 Romanovsky, A. A., Shido, O., Sakurada, S., Sugimoto, N. & Nagasaka, T. Endotoxin shock: thermoregulatory mechanisms. The American journal of physiolog y 270 , R693-703 (1996). 31 Corrigan, J. J., Fonseca, M. T., Flatow, E. A., Lewis, K. & Steiner, A. A. Hypometabolism and hypothermia in the rat model of endotoxic shock: independence of circulatory hypoxia. J Physiol 592 , 3901-3916, doi:10.1113/jphysiol.2014.277277 (2014). 32 Wagner, F., Asfar, P., Calzia, E., Radermacher, P. & Szabo, C. Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care. Critical care 13 , 213, doi:10.1186/ cc7700 (2009). 33 Wiewel, M. A. et al. Risk factors, host response and outcome of hypothermic sepsis. Critical care 20 , 328, doi:10.1186/s13054-016-1510-3 (2016). 34 Drewry, A. M., Fuller, B. M., Skrupky, L. P. & Hotchkiss, R. S. The Presence of Hypothermia Within 24 Hours of Sepsis Diagnosis Predicts Persistent Lymphopenia. Crit Care Med , doi:10.1097/ CCM.0000000000000940 (2015). 35 Marik, P. E. & Zaloga, G. P. Hypothermia and cytokines in septic shock. Norasept II Study Investigators. North American study of the safety and efficacy of murine monoclonal antibody to tumor necrosis factor for the treatment of septic shock. Intensive care medicine 26 , 716-721 (2000). 36 Drewry, A. M. et al. Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients With Severe Sepsis. Shock 50 , 381-387, doi:10.1097/shk.0000000000001083 (2018). 37 Laupland, K. B. et al. Severe hypothermia increases the risk for intensive care unit-acquired infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 54 , 1064-1070, doi:10.1093/cid/cir1033 (2012).