Matt Harmon

23 Chapter one 38 Kushimoto, S. et al. The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis. Critical care 17 , R271, doi:10.1186/cc13106 (2013). 39 Sprung, C. L. et al. Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med 18 , 801-806 (1990). 40 Kushimoto, S. et al. The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis. Critical care 17 , R271, doi:10.1186/cc13106 (2013). 41 Collins, K. J. et al. Accidental hypothermia and impaired temperature homoeostasis in the elderly. Br Med J 1 , 353-356 (1977). 42 Blatteis, C. M. Age-dependent changes in temperature regulation - a mini review. Gerontolog y 58 , 289-295, doi:10.1159/000333148 (2012). 43 Lee, B. H. et al. Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Critical care 16 , R33, doi:10.1186/cc11211 (2012). 44 Young, P. J. et al. Early peak temperature and mortality in critically ill patients with or without infection. Intensive care medicine 38 , 437–444, doi:10.1007/s00134-012-2478-3 (2012). 45 Leon, K., Moisan, C., Amerand, A., Poupon, G. & L’Her, E. Effect of induced mild hypothermia on two pro-inflammatory cytokines and oxidative parameters during experimental acute sepsis. Redox Rep 18 , 120-126, doi:10.1179/1351000213Y.0000000049 (2013). 46 Beurskens, C. J. P. et al. Induced hypothermia is protective in a rat model of pneumococcal pneumonia associated with increased adenosine triphosphate availability and turnover. Crit Care Med 40 , 919-926, doi:Doi 10.1097/Ccm.0b013e3182373174 (2012). 47 Yang, Y. L. et al. Body temperature control in patients with refractory septic shock: too much may be harmful. Chin Med J (Engl) 126 , 1809-1813 (2013). 48 Gao, Y. et al. Effects of Target Temperature Management on the Outcome of Septic Patients with Fever. BioMed research international 2017 , 3906032, doi:10.1155/2017/3906032 (2017). 49 Bisschops, L. L., Hoedemaekers, C. W., Mollnes, T. E. & van der Hoeven, J. G. Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance. Crit Care Med 40 , 1136-1142, doi:10.1097/CCM.0b013e3182377050 (2012). 50 Bouwes, A. et al. The influence of rewarming after therapeutic hypothermia on outcome after cardiac arrest. Resuscitation 83 , 996-1000, doi:10.1016/j.resuscitation.2012.04.006 (2012). 51 Polderman, K. H. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med 37 , S186-202, doi:10.1097/CCM.0b013e3181aa5241 (2009). 52 Chi, O. Z., Liu, X. & Weiss, H. R. Effects of mild hypothermia on blood-brain barrier disruption during isoflurane or pentobarbital anesthesia. Anesthesiolog y 95 , 933-938, doi:10.1097/00000542- 200110000-00023 (2001). 53 Bernard , S. A. et al. Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia. New England Journal of Medicine 346 , 557-563, doi:doi:10.1056/NEJMoa003289 (2002). 54 Hypothermia after Cardiac Arrest Study, G. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. The New England journal of medicine 346 , 549-556, doi:10.1056/ NEJMoa012689 (2002). 55 Nielsen, N. et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. The New England journal of medicine 369 , 2197-2206, doi:10.1056/NEJMoa1310519 (2013). 56 Link, M. S. et al. Part 7: Adult Advanced Cardiovascular Life Support: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 132 , S444-464, doi:10.1161/CIR.0000000000000261 (2015).