Matt Harmon

38 Chapter two References 1 Wiewel, M. A. et al. Risk factors, host response and outcome of hypothermic sepsis. Critical care 20 , 328, doi:10.1186/s13054-016-1510-3 (2016). 2 Fonseca, M. T. et al. Spontaneous hypothermia in human sepsis is a transient, self-limiting and non- terminal response. Journal of applied physiolog y , jap 00004 02016, doi:10.1152/japplphysiol.00004.2016 (2016). 3 Garami, A., Steiner, A. A. & Romanovsky, A. A. in Handbook of Clinical Neurolog y Vol. 157 (ed Andrej A. Romanovsky) 565-597 (Elsevier, 2018). 4 Beverly, A., Walter, E. & Carraretto, M. Management of hyperthermia and hypothermia in sepsis: A recent survey of current practice across UK intensive care units. Journal of the Intensive Care Society 17 , 88-89, doi:10.1177/1751143715601124 (2016). 5 Billeter, A. T. et al. Warming to 39 degrees C But Not to 37 degrees C Ameliorates the Effects on the Monocyte Response by Hypothermia. Ann Surg , doi:10.1097/SLA.0000000000001175 (2015). 6 Steiner, A. A., Fonseca, M. T. & Soriano, F. G. Should we assume that hypothermia is a dysfunction in sepsis? Critical care 21 , 8, doi:10.1186/s13054-016-1584-y (2017). 7 Romanovsky, A. A., Shido, O., Sakurada, S., Sugimoto, N. & Nagasaka, T. Endotoxin shock: thermoregulatory mechanisms. The American journal of physiolog y 270 , R693-703 (1996). 8 Almeida, M. C., Steiner, A. A., Branco, L. G. & Romanovsky, A. A. Cold-seeking behavior as a thermoregulatory strategy in systemic inflammation. Eur J Neurosci 23 , 3359-3367, doi:10.1111/j.1460- 9568.2006.04854.x (2006). 9 Liu, E. et al. Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation. American journal of physiolog y. Regulatory, integrative and comparative physiolog y 302 , R1372-1383, doi:10.1152/ajpregu.00023.2012 (2012). 10 Bisschops, L. L., Hoedemaekers, C. W., Mollnes, T. E. & van der Hoeven, J. G. Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance. Crit Care Med 40 , 1136-1142, doi:10.1097/CCM.0b013e3182377050 (2012).