Matt Harmon

44 Chapter two 23. How likely do you think the following mechanisms are in terms of the harmful effects of actively rewarming patients with spontaneous hypothermia during sepsis? 1 (Very unlikely) 2 (Unlikely) 3 (Neutral) 4 (Likely) 5 (Very likely) Ischemia/ reperfusion injury ¨ ¨ ¨ ¨ ¨ Increased shock ¨ ¨ ¨ ¨ ¨ Increased metabolism ¨ ¨ ¨ ¨ ¨ Randomized controlled trial The following questions regard the design of a randomized controlled trial (RCT) on rewarming strategies in patients with spontaneous hypothermia during sepsis. 24. Below which temperature would you include patients with spontaneous hypothermia during sepsis in an RCT? ¨ 37,0 °C ¨ 36,5 °C ¨ 36,0 °C ¨ 35,5 °C ¨ 35,0 °C ¨ 34,5 °C ¨ 34,0 °C 25. What is the maximum temperature to which you would actively rewarm patients with spontaneous hypothermia during sepsis in an RCT? ¨ 35,5 °C ¨ 36,0 °C ¨ 36,5 °C ¨ 37,0 °C ¨ 37,5 °C ¨ >38,0 °C 26. Is an RCT warranted to examine the effect of different rewarming strategies in patients with spontaneous hypothermia during sepsis? ¨ Yes ¨ No ¨ Don’t know