Matt Harmon

53 Chapter three Table 2). Interestingly, hypertension (adjusted odds ratio (aOR) 1.98; 95%CI 1.30- 3.02) and chronic cardiovascular insufficiency (aOR 3.27; 95%CI 1.25-8.50) were associated with hypothermia. BMI was inversely correlated with hypothermia (aOR 0.96; 95% confidence interval (CI) 0.93-0.99). Age was not independently associated with hypothermia (aOR 1.01; 95%CI 0.999-1.03). Hypothermia on admission is associated with increased mortality ICU- and hospital mortality were significantly higher in septic patients with hypothermia (Supplemental Table 3). There were differences in mortality at 30, 60 and 90 days and at 1 year after ICU admission (Figure 1 and Supplemental Table 3). There was an increased incidence of AKI during admission in patients with hypothermia. There was no difference in the incidence of ICU-acquired infections. Multivariable logistic regression including APACHE IV scores was performed to determine if hypothermia was independently associated with mortality. Site of infection was a confounder in our study and thus was retained in the model (Supplemental table 4). Hypothermia was independently associated with an increased risk of death at 90 days (aOR 2.08; 95%CI 1.38-3.16). Figure 1 . Survival curve in patients with and without hypothermia during the first 24 hours of ICU admission. Hypothermia No. at risk Days Proportion alive 0.00 0.25 0.50 0.75 1.00 0 15 30 45 60 75 90 No hypothermia 339 186 291 129 279 116 268 109 264 103 256 101 248 97 *** Kaplan–Meier plot of survival time up to 90 days after intensive care unit admission. *** P < 0.001.