Matt Harmon

54 Chapter three Table 1. Baseline characteristics of sepsis patients with and without hypothermia during the first 24 hours of admission Hypothermia No hypothermia p N = 186 N = 339 Demographics Age, years, mean [SD] 65.0 [13.8] 61.1 [15.6] .004 Gender, male (%) 114 (61.3) 206 (60.8) .94 BMI, kg/m2, mean [SD] 25.6 [5.7] 26.7 [6.7] .04 Comorbidities Charlson score, median [IQR] 5 [3-6] 4 [2-6] .01 Cerebrovascular disease (%) 28 (15.1) 27 (8) .01 Chronic cardiovascular insufficiency (%) 13 (7) 7 (2.1) .009 Chronic renal insufficiency (%) 26 (14) 32 (9.4) .15 Congestive heart failure (%) 8 (4.3) 17 (5) .84 COPD (%) 29 (15.6) 61 (18) .55 Diabetes mellitus (%) 42 (22.6) 67 (19.8) .51 Hypertension (%) 73 (39.2) 87 (25.7) .003 Liver cirrhosis 7 (3.8) 6 (1.8) .23 Peripheral vascular disease (%) 25 (13.4) 44 (13) .90 Admission Admission type, medical (%) 163 (87.6) 298 (87.9) .55 Admission origin, emergency department (%) 74 (39.8) 99 (29.2) .04 medium care (%) 26 (14) 47 (13.9) ward (%) 86 (46.2) 193 (56.9) Site of infection Pulmonary (%) 79 (42.5) 161 (47.5) .28 Abdominal (%) 29 (15.6) 65 (19.2) .34 Urinary tract (%) 32 (17.2) 33 (9.7) .02 Other (%) 18 (9.7) 44 (13) .31 Co-infection (%) 28 (15.1) 36 (10.6) .15 Severity of disease first 24h Mean temperature first 6 h, median [IQR] 36.1 [35.4-37] 37.2 [36.5-38] <.0001 Mean temperature first 24 h, median [IQR] 36.3 [35.8-36.9] 37.3 [36.8-37.8] <.0001 APACHE IV score, median [IQR] a 82 [67-103] 71 [58-86] <.0001 SOFA score, median [IQR] b 8 [5-10] 7 [4-8] <.001 Acute kidney injury (%) 92 (49.5) 118 (34.8) .002 Renal replacement therapy (%) 32 (17.1) 21 (6.2) <.001 Acute lung injury (%) 49 (26.3) 99 (29.2) .57 Shock (%) 74 (39.8) 106 (31.3) .06 Table continues on next page