Matt Harmon

55 Chapter three Table 1. Continued. Hypothermia No hypothermia p N = 186 N = 339 Clinical laboratory parameters first 24h WBC count max.( x10^9/l), median [IQR] 16.1 [10.9-25.5] 14.9 [10-19.2] .02 WBC count min.( x10^9/l), median [IQR] 12.6 [7.1-19.1] 12.2 [7.7-16.2] .25 Platelets min. (x10^9/l), median [IQR] 189 [120-264] 199 [131-283] .27 Lactate max. (mmol/l), median [IQR] 3.2 [1.6-6.5] 2.5 [1.6-4.1] .009 Prothrombin time max. (s), median [IQR] 16.5 [14.1-20.7] 15 [12.6-18.2] .0001 Creatinine max. (μmol/l), median [IQR] 121 [80-209] 97 [68-162] <.001 C-reactive protein (mg/l), median [IQR] 146 [82-258] 174 [98-263] .25 APACHE, acute physiology and chronic health evaluation; COPD, chronic obstructive pulmonary disease; IQR, interquartile range; SD, standard deviation; SOFA, sequential organ failure assessment; WBC, white blood cell. a Temperature not included in score b Central nervous system not included in score due to large number of sedated patients Hypothermic sepsis is not associated with altered anti-inflammatory or proinflammatory cytokine plasma levels Levels of IL-13 were undetectable or low in the majority of patients and were not different between groups. Levels of IL-10 were increased in sepsis patients compared to healthy subjects, however there was no association with the presence of hypothermia (Figure 2). Proinflammatory cytokines TNF- α and IL-1 β were also undetectable or low in the majority of patients and were not different between groups. IL-6 and IL-8 levels were increased in patients with sepsis however there was also no association with the presence of hypothermia (Figure 2).