Matt Harmon

58 Chapter three Figure 4 . Endothelial cell activation in sepsis patients stratified according to the presence of hypothermia. days after admission Fractalkine soluble ICAM-1 days after admission days after admission soluble E-selectin 10 1 10 2 10 3 10 4 10 5 10 6 0 2 4 Angiopoietin-1 (pg/ml) days after admission 10 −2 10 −1 10 0 10 1 10 2 10 3 10 4 0 2 4 Ang-2 / Ang-1 (pg/ml) 10 2 10 3 10 4 10 5 10 6 0 2 4 Angiopoietin-2 (pg/ml) days after admission days after admission Angiopoietin-1 Angiopoietin-2 Ang-2 / Ang-1 10 0 10 0.5 10 1 10 1.5 10 2 10 2.5 10 3 0 2 4 Fractalkine (pg/ml ) 10 4 10 4.5 10 5 10 5.5 10 6 10 6.5 10 7 0 2 4 sICAM−1 (pg/ml ) 10 2 10 3 10 4 10 5 10 6 0 2 4 sEselectin−1 (pg/ml) * * *** *** *** Healthy subjects No hypothermia Hypothermia Box-and-whisker diagrams depict the median and lower quartile, upper quartile and respective 1.5 IQR as whiskers. Dashed lines represent median levels in 27 healthy volunteers. ICAM-1 intercellular adhesion molecule-1. Note: soluble ICAM-1 is also derived from leukocytes. *** P < 0.001, * P < 0.05.