Matt Harmon

65 Chapter three Supplemental Table 3. Outcomes of sepsis patients with and without hypothermia during the first 24 hours of admission Hypothermia No hypothermia P N = 186 N = 339 Acute kidney injury (%) 105 (56.5) 137 (40.4) .002 Renal replacement therapy (%) 40 (21.5) 41 (12.1) .005 Acute lung injury (%) 25 (31.2) 113 (33.3) .62 ICU-acquired weakness (%) 13 (7) 20 (5.9) .72 ICU-acquired infections (%) 15 (8.1) 24 (7.1) .72 ICU-mortality (%) 48 (25.8) 38 (11.2) <.001 Hospital mortality (%) 69 (37.1) 69 (20.4) <.001 30 day mortality (%) 66 (35.5) 59 (17.4) <.001 60 day mortality (%) 78 (41.9) 74 (21.8) <.001 90 day mortality (%) 84 (45.2) 87 (25.7) <.001 1 year mortality (%) 104 (55.9) 122 (36) <.001 Supplemental Table 4. Association between hypothermia and 90-day mortality in patients with sepsis, adjusted for confounders OR 95% CI P Hypothermia 2.47 1.69 – 3.61 <.0001 Hypothermia + APACHE IV score a 1.91 1.28 – 2.87 .0017 Hypothermia + APACHE IV score a + Site of infection 2.08 1.38 – 3.16 .0005 APACHE, acute physiology and chronic health evaluation. a Temperature not included in score Supplemental Table 5. Clinical characteristics of sepsis patients included in ex vivo whole blood stimulation analysis. Hypothermia No hypothermia N = 5 N = 10 Demographics Age, years, mean [SD] 61.4 [12.9] 67.1 [13.7] Gender, male (%) 1 (20) 6 (60) BMI, kg/m2, mean [SD] 29.1 [9.8] 29.3 [8.9] Charlson score, median [IQR] 3 [0-3] 2 [0-3] Table continues on next page