Matt Harmon

66 Chapter three Supplemental Table 5. Continued. Hypothermia No hypothermia N = 5 N = 10 Site of infection Pulmonary (%) 2 (40) 6 (60) Abdominal (%) 0 (0) 1 (10) Urinary tract (%) 2 (40) 2 (20) Other (%) 5 (100) 10 (100) Co-infection (%) 1 (20) 1 (10) Severity of disease first 24h Mean temperature first 6 h, median [IQR] 36.1 [35-36.9] 37.1 [36.9-38] Mean temperature first 24 h, median [IQR] 36 [35.6-36.3] 37.4 [37.2-37.8] APACHE IV score, median [IQR] a 75 [65-113] 73 [63-80] SOFA score, median [IQR] b 9 [8-9] 7.5 [6-9] Acute kidney injury (%) 3 (60) 4 (40) Acute lung injury (%) 2 (40) 4 (40) Shock (%) 1 (20) 4 (40) Clinical laboratory parameters first 24h WBC count max.( x10^9/l), median [IQR] 13.1 [8.3-13.5] 12.2 [10.5-18.8] WBC count min.( x10^9/l), median [IQR] 9.4 [7-12.7] 9.2 [7.8-15.2] Platelets min. (x10^9/l), median [IQR] 109 [72-276] 158 [138-199] Lactate max. (mmol/l), median [IQR] 1.1 [1.1-1.9] 2.4 [2.124] Prothrombin time max. (s), median [IQR] 16 [13.5-16.7] 16.8 [12.1-19.9] Creatinine max. (μmol/l), median [IQR] 257 [200-421] 113 [88-142] C-reactive protein (mg/l), median [IQR] 160 [128-219] 128 [71-177] Outcome ICU-mortality (%) 1 (20) 1 (10) Hospital mortality (%) 2 (40) 4 (40) 30 day mortality (%) 2 (40) 2 (20) 60 day mortality (%) 3 (60) 3 (30) 90 day mortality (%) 3 (60) 4 (40) 1 year mortality (%) 3 (60) 4 (40) APACHE, acute physiology and chronic health evaluation; IQR, interquartile range; SD, standard deviation; SOFA, sequential organ failure assessment; WBC, white blood cell. a Temperature not included in score b Central nervous system not included in score due to large number of sedated patients