Matt Harmon

Contents Chapter 1 General introduction and outline of this thesis 9 Part I Chapter 2 Opinions and Management of Hypothermic Sepsis: Results from an Online Survey 29 Chapter 3 Risk factors, host response and outcome of hypothermic sepsis 47 Chapter 3a Should we assume that hypothermia is a dysfunction in sepsis? 69 Chapter 3b The authors reply 71 Chapter 4 Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis 75 Part II Chapter 5 Physiologic and host immune effects of induced normothermia in human endotoxemia 99 Chapter 6 Induced normothermia ameliorates the procoagulant host response in human endotoxemia. 117 Part III Chapter 7 Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: A substudy of the targeted temperature management trial 135 Chapter 8 Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy 155 Chapter 9 Microbiological profile of nosocomial infections following cardiac arrest: Insights from the targeted temperature management (TTM) trial 177 Chapter 10 Summary and general discussion 199 Chapter 11 Nederlandse samenvatting 211 Appendices List of publications 218 Curriculum Vitae 220 PhD portfolio 221 Acknowledgements 223