Matt Harmon

Chapter four 80 Table 1. Baseline characteristics and outcome of sepsis patients according to different temperatures Hypothermia N=67 Normothermia N= 75 Fever N=101 Both N=18 P-value Demographics Age, years, mean [SD] 68.1 [10.9] 64.7 [14.6] 60.0 [16.6] 58.1 [17.3] 0.002 Gender, male (%) 37 (55) 34 (45) 66 (65) 12 (67) 0.051 BMI, kg/m2, mean [SD] 25.5 [5.5] 25.9 [6.4] 27.0 [7.3] 27.1 [7.2] 0.498 Comorbidities Charlson score, median [IQR] 5 [3-6] 4 [3-7] 4 [2-6] 3 [2-4] 0.003 Chronic cardiovascular insufficiency (%) 4 (6) 2 (3) 2 (2) 4 (22) 0.003 Chronic renal insufficiency (%) 11 (16) 12 (16) 6 (6) 2 (11) 0.109 Congestive heart failure (%) 3 (4) 3 (4) 4 (4) 1 (6) 1 COPD (%) 9 (13) 16 (21) 17 (17) 2 (11) 0.57 Diabetes mellitus (%) 19 (28) 16 (21) 16 (16) 4 (22) 0.276 Site of infection Pulmonary (%) 28 (42) 31 (41) 50 (50) 6 (33) 0.524 Abdominal (%) 13 (19) 19 (25) 21 (21) 3 (17) - Urinary tract (%) 10 (15) 10 (13) 9 (9) 3 (17) - Other (%) 3 (4) 9 (12) 8 (8) 3 (17) - Co-infection (%) 13 (19) 6 (8) 13 (13) 3 (17) - Severity of disease first 24h Min temp first 24 h, mean [SD] 35.0 [0.9] 36.6 [0.5] 37.2 [0.7] 34.9 [0.7] <0.0001 Max temp first 24 h, mean [SD] 37.1 [0.9] 37.6 [0.9] 39.3 [0.9] 38.8 [0.9] <0.0001 APACHE IV score, median [IQR] a 82 [71.5-104.5] 80 [66.5-93.5] 68 [55-84] 92 [65.8-111.3] <0.0001 SOFA score, median [IQR] b 9 [6-11] 8 [4-10] 7 [4-8] 6[4-11] 0.001 Acute kidney injury (%) 38 (57) 28 (37) 31 (31) 9 (50) 0.009 Renal replacement therapy (%) 14 (21) 4 (5) 8 (8) 4 (22) 0.008 Table continues on next page