Matt Harmon

Chapter four 92 39 Rai, A. N. et al. Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia. Scientific Reports 6 , 26964, doi:10.1038/ srep26964 https://www.nature.com/articles/srep26964#supplementary- information (2016). 40 Shah, P., Nanduri, B., Swiatlo, E., Ma, Y. & Pendarvis, K. Polyamine biosynthesis and transport mechanisms are crucial for fitness and pathogenesis of Streptococcus pneumoniae. Microbiolog y 157 , 504-515, doi:10.1099/mic.0.042564-0 (2011). 41 Shah, P. & Swiatlo, E. A multifaceted role for polyamines in bacterial pathogens. Mol Microbiol 68 , 4-16, doi:10.1111/j.1365-2958.2008.06126.x (2008). 42 Rath, T., Roth, E., Keidl, R. & Meissl, G. Phenylalanine: total amino acid ratio in 45 burn patients. Scand J Plast Reconstr Surg Hand Surg 21 , 297-300 (1987). 43 Ploder, M. et al. Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations. Amino acids 35 , 303-307, doi:10.1007/s00726-007-0625-x (2008). 44 Huang, S. S. et al. Phenylalanine- and leucine-defined metabolic types identify high mortality risk in patients with severe infection. Int J Infect Dis 85 , 143-149, doi:10.1016/j.ijid.2019.05.030 (2019). 45 Strasser, B., Sperner-Unterweger, B., Fuchs, D. & Gostner, J. M. Mechanisms of Inflammation- Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms. Curr Top Behav Neurosci 31 , 95-115, doi:10.1007/7854_2016_23 (2017). 46 Fonseca, M. T. et al. Spontaneous hypothermia in human sepsis is a transient, self-limiting and non- terminal response. Journal of applied physiolog y , jap 00004 02016, doi:10.1152/japplphysiol.00004.2016 (2016). 47 Scicluna, B. P. et al. Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study. Lancet Respir Med 5 , 816-826, doi:10.1016/S2213-2600(17)30294-1 (2017). 48 Tiruvoipati, R. et al. Hypothermia predicts mortality in critically ill elderly patients with sepsis. BMC geriatrics 10 , 70, doi:10.1186/1471-2318-10-70 (2010).