Matt Harmon

Chapter 1 General introduction and outline of this thesis 9
Chapter 2 Opinions and Management of Hypothermic Sepsis: Results from an Online Survey 29
Chapter 3 Risk factors, host response and outcome of hypothermic sepsis 47
Chapter 4 Patients with hypothermic sepsis have a unique gene expression profile compared to patients with fever and sepsis 75
Chapter 5 Physiologic and host immune effects of induced normothermia in human endotoxemia 99
Chapter 6 Induced normothermia ameliorates the procoagulant host response in human endotoxemia. 117
Chapter 7 Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: A substudy of the targeted temperature management trial 135
Chapter 8 Carbon dioxide dynamics in relation to neurological outcome in resuscitated out-of-hospital cardiac arrest patients: an exploratory Target Temperature Management Trial substudy 155
Chapter 9 Microbiological profile of nosocomial infections following cardiac arrest: Insights from the targeted temperature management (TTM) trial 177
Chapter 10 Summary and general discussion 199
Chapter 11 Nederlandse samenvatting 211
List of publications 218
Curriculum Vitae 220
PhD portfolio 221
Acknowledgements 223

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