Ires Ghielen

157 BEWARE: Results of the pilot RCT References 1. Barone, P., et al., The Priamo Study: A Multicenter Assessment of Nonmotor Symptoms and Their Impact on Quality of Life in Parkinson’s Disease. Movement Disorders, 2009. 24 (11): p. 1641-1649. 2. Olanow, C.W., R.L. Watts, and W.C. Koller, An algorithm (decision tree) for the management of Parkinson’s disease (2001): Treatment guidelines. Neurology, 2001. 56 (11): p. S1-S88. 3. Stocchi, F., et al., Early DEtection of wEaring off in Parkinson disease: The DEEP study. Parkinsonism & Related Disorders, 2014. 20 (2): p. 204-211. 4. Witjas, T., et al., Nonmotor fluctuations in Parkinson’s disease - Frequent and disabling. Neurology, 2002. 59 (3): p. 408-413. 5. Richard, I., Frank, S, McDermott, MP, Wang, H, Justus, AW, LaDonna, KA, Kurlan, R The ups and downs of Parkinson disease. A prospective study of mood and anxiety fluctuations. . Cognitive Behavioral Neurology 2004. 17 : p. 201-207. 6. Lutz, S.G., et al., Clinical Presentation of Anxiety in Parkinson’s Disease: A Scoping Review. Otjr-Occupation Participation and Health, 2016. 36 (3): p. 134-147. 7. Rutten, S., et al., Anxiety in Parkinson’s disease: Symptom dimensions and overlap with depression and autonomic failure. Parkinsonism & Related Disorders, 2015. 21 (3): p. 189-193. 8. Mehling, W.E., et al., Body Awareness: Construct and Self-Report Measures. Plos One, 2009. 4 (5). 9. Clark, D.M., Anxiety disorders: why they persist and how to treat them. Behaviour Research and Therapy, 1999. 37 : p. S5-S27. 10. Brown, R., Marsden, CD, Quinn, N, Wyke, MA, Alterations in cognitive performance and affect-arousal state during fluctuations in motor function in Parkinson’s disease. Journal of neurology, neurosurgery and psychiatry, 1989. 47 : p. 454- 465. 11. Maricle, R.A., et al., Dose-Response Relationship of Levodopa with Mood and Anxiety in Fluctuating Parkinsons-Disease - a Double-Blind, Placebo-Controlled Study. Neurology, 1995. 45 (9): p. 1757-1760. 12. Schrag, A., A. Sauerbier, and K.R. Chaudhuri, New Clinical Trials for Nonmotor Manifestations of Parkinson’s Disease. Movement Disorders, 2015. 30 (11): p. 1490-1503. 13. Seppi, K., et al., The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the Non-Motor Symptoms of Parkinson’s Disease. Movement Disorders, 2011. 26 : p. S42-S80. 14. van Laar, T., Levodopa-induced response fluctuations in patients with Parkinson’s disease - Strategies for management. Cns Drugs, 2003. 17 (7): p. 475-489. 8