Ires Ghielen

47 Replication factor analysis in neuropsychiatric PD patients Table 2. Psychiatric diagnoses as given by assessing psychiatrist (N = 123) Diagnosis given (DSM-IV or –V) % No diagnosis 8.1 Anxiety disorders 52.9 Due to somatic disorder (PD) 41.5 Panic disorder 6.5 Generalized anxiety disorder 3.3 Social anxiety disorder 1.6 Depressive disorders 41.4 Due to somatic disorder (PD) 25.2 Persistent depressive disorder (dysthymia) 0.8 Major depressive disorder 15.4 Neurocognitive disorder 31.7 Other specified disruptive, impulse-control and conduct disorder* 16.3 Psychotic disorder 12.9 Sleep-wake disorder 15.4 * all patients fulfilling criteria for this DSM category had an impulse control disorder Of these 65 patients, 79.3% received at least one other psychiatric diagnosis. Depressive disorders were the most frequent occurring comorbidity, as they were diagnosed in 42.3% of patients with an anxiety disorder. Based on both BAI and BDI total scores, 62.4% of the patients had clinically relevant symptoms of both anxiety and depression. Principal component analysis of the BAI Examination of the scree-plot and the Eigenvalue greater than 1 rule suggested five factors. All BAI-items had a loading greater than 0.4 on at least one of the factors and therefore all items were included in the factor solution. No items had a loading greater than 0.4 on multiple factors. The five extracted factors were considered subscales with the following labels; affective, thermoregulation, cardiopulmonary, unsteadiness and ‘undefined’ . The last factor included three items (i.e. dizzy/lightheaded, faint/lightheaded, and indigestion) that we could not clinically interpret as an evident subdomain of anxiety. Therefore, we decided not to label this as a subscale and excluded it from further analyses. The factor solution explained a total of 64.6% of the variance, 59.1% excluding the last factor, with the affective subscale explaining 35.9% of the total 3