Ires Ghielen

72 Chapter 4 Conclusion In this explorative network comparison analysis, we found a higher global strength in the high-anxious PD patients. No differences were found in the associations between motor and anxiety symptoms in high-anxiety versus low-anxiety PD patient groups. The two groups differed in multiple descriptive and clinical characteristics, which is representative for clinical practice and indicates that specific motor and anxiety symptoms are intertwined independent of anxiety level. Due to the small sample sizes, instability of the network structures, and possible Berkson’s bias, these results need to be interpreted with caution. Further research is necessary to replicate in an independent bigger sample and to understand network architecture characteristics related to response fluctuations over time.