Franny Jongbloed

101 4 A PROTEIN-FREE DIET PROTECTS AGAINST RENAL IRI 16. Kosieradzki, M. & Rowinski, W. Ischemia/reperfusion injury in kidney transplantation: mechanisms and prevention. Transplant Proc 40, 3279-3288, doi:10.1016/j. transproceed.2008.10.004 (2008). 17. Snoeijs, M. G., van Heurn, L. W. & Buurman, W. A. Biological modulation of renal ischemia-reperfusion injury. Curr Opin Organ Transplant 15, 190-199, doi:10.1097/ MOT.0b013e32833593eb (2010). 18. Mair, W., Piper, M. D. & Partridge, L. Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol 3, e223, doi:10.1371/journal.pbio.0030223 (2005). 19. Peng, W. et al. Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice. Sci Transl Med 4, 118ra111, doi:10.1126/scitranslmed.3002629 (2012). 20. Xia, J. et al. INMEX--a web-based tool for integrative meta-analysis of expression data. Nucleic Acids Res 41, W63-70, doi:10.1093/nar/gkt338 (2013). 21. Gallinetti, J., Harputlugil, E. & Mitchell, J. R. Amino acid sensing in dietary-restriction- mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem J 449, 1-10, doi:BJ20121098 [pii] 10.1042/BJ20121098 (2013). 22. Kennedy, B. K. &Lamming, D.W.TheMechanistic Target of Rapamycin:TheGrandConducTOR of Metabolism and Aging. Cell Metab 23, 990-1003, doi:S1550-4131(16)30227-3 [pii] 10.1016/j. cmet.2016.05.009 (2016). 23. Xu, S., Cai, Y. & Wei, Y. mTOR Signaling from Cellular Senescence to Organismal Aging. Aging Dis 5, 263-273, doi:10.14336/AD.2014.0500263 ad-5-4-263 [pii] (2014). 24. Hay, N. & Sonenberg, N. Upstream and downstream of mTOR. Genes Dev 18, 1926-1945, doi:10.1101/gad.1212704 18/16/1926 [pii] (2004). 25. Wullschleger, S., Loewith, R. & Hall, M. N. TOR signaling in growth and metabolism. Cell 124, 471-484, doi:S0092-8674(06)00108-5 [pii] 10.1016/j.cell.2006.01.016 (2006). 26. Solon-Biet, S. M. et al. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab 19, 418-430, doi:10.1016/j. cmet.2014.02.009 (2014). 27. Longo, V. D. et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14, 497- 510, doi:10.1111/acel.12338 (2015). 28. Masoro, E. J. Caloric restriction and aging: controversial issues. J Gerontol A Biol Sci Med Sci 61, 14-19 (2006). 29. Cavallini, G., Donati, A., Gori, Z. & Bergamini, E. Towards an understanding of the anti-aging mechanism of caloric restriction. Curr Aging Sci 1, 4-9 (2008). 30. Turturro, A., Hass, B. S. & Hart, R. W. Does caloric restriction induce hormesis? Hum Exp Toxicol 19, 320-329 (2000). 31. Zhu, Z. et al. PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein. Biochem Biophys Res Commun 358, 66-72, doi:10.1016/j.bbrc.2007.04.096 (2007).

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