Franny Jongbloed

111 4 A PROTEIN-FREE DIET PROTECTS AGAINST RENAL IRI Table S2. Top 10 overrepresented canonical pathways after fasting, dietary restriction and macronutrient free diets individually ranked by their –log P- value Canonical Pathway P- value Genes Ratio 3-day FASTING Superpathway Cholesterol Biosynthesis 3.41 E -08 14/87 (16.1%) Cholesterol Biosynthesis I / II / III 2.18 E -06 8/40 (20.0%) LXR / RXR Activation 2.20 E -06 27/139 (19.4%) NRF2-mediated Oxidative Stress Response 6.27 E -06 34/195 (17.4%) LPS/IL-1 Mediated Inhibition of RXR Function 7.46 E -06 39/245 (15.9%) Acute Phase Response Signaling 7.24 E -05 30/181 (16.6%) GADD45 Signaling 1.25 E -04 8/24 (33.3%) AMPK Signaling 1.25 E -04 25/180 (13.9%) VDR/RXR Activation 2.18 E -04 17/88 (19.3%) Xenobiotic Metabolism Signaling 3.00 E -04 42/304 (13.8%) 2-week 30% DR Circadian Rhythm Signaling 1.41 E -05 6/38 (15.8%) Aldosterone Signaling Epithelial Cells 3.20 E -05 11/168 (6.5%) Guanosine Nucleotides Degradation II 7.85 E -04 3/22 (13.6%) Urate Biosynthesis 1.01 E -03 3/22 (13.6%) Phenylalanine Degradation IV 1.27 E -03 3/39 (7.7%) 2-ketoglutarate Dehydrogenase Complex 1.48 E -03 2/9 (22.2%) Adenosine Nucleotides Degradation II 1.57 E -03 3/26 (11.5%) NRF2-mediated Oxidative Stress Response 2.39 E -03 9/195 (4.6%) Protein Ubiquitination Pathway 2.63 E -03 11/270 (4.1%) Purine Nucleotides Degradation II 2.71 E -03 3/35 (8.6%) 3-day PROTEIN-FREE Intrinsic Prothrombin Activation Pathway 5.18 E -04 4/37 (10.8%) Superpathway Cholesterol Biosynthesis 6.79 E -04 4/87 (4.6%) LPS/IL-1 Mediated Inhibition of RXR Function 8.81 E -04 10/245 (4.1%) Mevalonate Pathway I 9.87 E -04 3/29 (10.3%) Creatine-phosphate Biosynthesis 1.77 E -03 2/9 (22.2%) Superpathway of Geranylgeranyl 2.02 E -03 3/37 (8.1%) PXR/RXR Activation 2.12 E -03 5/92 (5.4%) GADD45 Signaling 2.35 E -03 3/24 (12.5%) Tryptophan Degradation 4.84 E -03 2/18 (11.1%) Nicotine Degradation II 9.33 E -03 4/85 (4.7%)