Franny Jongbloed

112 CHAPTER 4 Table S2. (continued) Canonical Pathway P- value Genes Ratio 3-day CARBOHYDRATE-FREE Histamine Degradation 9.52 E -05 6/29 (20.7%) Pyrimidine Deoxygenase De Novo Biosynthesis I 1.57 E -04 6/34 (17.6%) Superpathway of Serine and Glycine Biosynthesis I 2.57 E -04 4/18 (22.2%) Glycolysis I 6.98 E -04 7/41 (17.1%) NRF2-mediated Oxidative Stress Response 8.17 E -04 24/195 (12.3%) Cholesterol Biosynthesis I / II / III 1.04 E -03 5/40 (12.5%) Colanic Acid Building Blocks Biosynthesis 1.52 E -03 5/36 (13.9%) Fatty Acid β-oxidation 1.52 E -03 5/21 (23.8%) Protein Ubiquitination Pathway 1.58 E -03 30/270 (11.1%) Folate Transformations I 1.84 E -03 4/32 (12.5%) 3-day 30% DR Dopamine Degradation 1.08 E -04 5/35 (14.3%) Aryl Hydrocarbon Receptor Signaling 1.37 E -04 9/140 (6.4%) LPS/IL-1 Mediated Inhibition of RXR Function 2.48 E -04 11/221 (5.0%) PXR/RXR Activation Circadian Rhythm Signaling 2.63 E -04 1.03 E -03 6/65 (9.2%) 4/33 (12.1%) NRF2-mediated Oxidative Stress Response 1.42 E -03 9/193 (4.7%) Tyrosine Degradation I 1.82 E -03 2/5 (40.0%) Histamine Degradation 2.09 E -03 3/19 (15.8%) Noradrenaline and Adrenaline Degradation 2.14 E -03 4/40 (10.0%) Adipogenesis Pathway 2.52 E -03 7/134 (5.2%) Top 10 overrepresented pathways after dietary restriction and macronutrient free diets, with the exception of the 3-day fat-free diet that showed no differentially expressed probe sets. Analysis revealed no pathways regulated in common between the three protective diets. Furthermore, no pathways were oppositely regulated in the non-protective CHO-free diet. Genes ratio is the number and percentage of genes differentially expressed in ratio to the total number of genes involved in the pathway.