Franny Jongbloed

127 5 ABSENCE OF PROTEIN AND AMINO ACIDS PROTECT AGAINST HEPATIC IRI Table 1. (continued) Canonical Pathway Pathway Classification P- value Genes Ratio Z-score Thrombin Signaling Cardiovascular Signaling 1.11 E -02 13/203 (6.4%) +0.905 LXR/RXR Activation Nuclear Receptor Signaling 1.31 E -02 9/121 (7.4%) -1.000 CXCR4 Signaling Cellular Immune Response / Cytokine Signaling 1.42 E -02 11/165 (6.7%) +0.378 Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle Regulation 1.76 E -02 5/49 (10.2%) +1.000 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages Cellular Immune Response 1.77 E -02 12/193 (6.2%) -0.302 PI3K Signaling in B Lymphocytes Cellular Immune Response 1.85 E -02 9/128 (7.0%) -0.333 G Beta Gamma Signaling Intracellular and Second Messenger Signaling 1.96 E -02 7/88 (8.0%) +0.378 Relaxin Signaling Organismal Growth and Development / Growth Factor Signaling 2.05 E -02 10/152 (6.6%) -0.447 Colorectal Cancer Metastasis Signaling Cancer 2.27 E -02 14/247 (5.7%) +0.577 Actin Nucleation by ARP-WASP Complex Intracellular and Second Messenger Signaling 2.96 E -02 5/56 (8.9%) +1.342 Synaptic Long Term Potentiation Neurotransmitters and Other Nervous System Signaling 3.36 E -02 8/120 (6.7%) +0.707 Dendritic Cell Maturation Cytokine Signaling/ Cellular Immune Response 3.55 E -02 11/190 (5.8%) +1.897 ICOS-ICOSL Signaling in T Helper Cells Cellular Immune Response 3.65 E -02 8/122 (6.6%) +1.890 Sphingosine-1-phosphate Signaling Intracellular and Second Messenger Signaling 3.81 E -02 8/123 (6.5%) +1.414 Macropinocytosis Signaling Cellular Immune Response 4.01 E -02 6/81 (7.4%) +1.000 UV-Induced MAPK Signaling Cellular Stress and Injury 4.07 E -02 4/42 (9.5%) -1.000 Antioxidant Action of Vitamin C Cellular Stress and Injury 4.14 E -02 7/103 (6.8%) -1.000 RhoGDI Signaling Intracellular and Second Messenger Signaling 4.40 E -02 10/173 (5.8%) -0.378 IL-8 Signaling Cytokine Signaling 4.42 E -02 11/197 (5.6%) +1.508 ERK5 Signaling Intracellular and Second Messenger Signaling 4.58 E -02 5/63 (7.9%) +0.447 Tryptophan-free LPS/IL-1 Mediated Inhibition of RXR Function Nuclear Receptor Signaling 1.25 E -05 23/222 (10.4%) -1.667