Franny Jongbloed

128 CHAPTER 5 Table 1. (continued) Canonical Pathway Pathway Classification P- value Genes Ratio Z-score NRF2-mediated Oxidative Stress Response Cellular Stress and Injury 1.40 E -05 21/193 (10.9%) +1.941 Colorectal Cancer Metastasis Signaling Cancer 4.77 E -04 21/247 (8.5%) -0.447 Sumoylation Pathway Cellular Stress and Injury/ Transcriptional Regulation 9.90 E -04 11/96 (11.5%) +0.333 Calcium-induced T Lypmhocyte Apoptosis Apoptosis/Cellular Immune Response 3.32 E -03 8/66 (12.1%) +1.134 LXR/RXR Activation Nuclear Receptor Signaling 2.11 E -03 12/121 (9.9%) -0.447 Wnt/B-catenin Signaling Cancer / Organismal Growth and Development 1.20 E -02 13/169 (7.7%) -0.333 Cholecystokinin/Gastrin- mediated Signaling Neurotransmitters and Other Nervous System Signaling 1.42 E -02 9/101 (8.9%) -0.333 MIF Regulation of Innate Immunity Cellular Immune Response 1.85 E -02 5/41 (12.2%) +1.342 IGF-1 Signaling Growth Factor Signaling 1.90 E -02 9/106 (8.5%) +0.447 UVC-Induced MAPK Signaling Cellular Stress Injury 2.04 E -02 5/42 (11.9%) -1.342 MIF-mediated Glucocorticoid Regulation Cellular Immune Response / Nuclear Receptor Signaling 3.47 E -02 4/33 (12.1%) +2.000 Cell Cycle: G2/M DNA Damage Checkpoint Regulation Cell Cycle Regulation 3.69 E -02 5/49 (10.2%) +2.000 Mitotic Roles of Polo-Like Kinase Cell Cycle Regulation 3.81 E -02 6/66 (9.1%) -2.000 TWEAK Signaling Apoptosis / Cytokine Signaling 3.82 E -02 4/34 (11.8%) -1.000 Sphingosine-1-phosphate Signaling Intracellular and Second Messenger Signaling 4.36 E -02 9/123 (7.3%) +0.707 Pathways are defined via the canonical pathways and pathway classification. Only pathways with a z-score were included. Analyses are based on the analyses done in Ingenuity and Ingenuity Target Explorer. Genes ratio = the number and percentage of probe sets differentially expressed in ratio to the total number of genes involved in the pathway. Z-score = based on the observed gene expression changes in the specific array datasets.