Franny Jongbloed

134 CHAPTER 5 activation of the upstream transcription regulators are calculated via de statistical z-score based on the observed gene expression changes in our dataset. Calculating the z-score reduces the chance of significant predictions based on random data (http://ingenuity.force. com/ipa/articles/Feature_Description/Upstream-Regulator-Analysis). A z-score ≥ 2 or ≤-2 was set as significant.