Franny Jongbloed

135 5 ABSENCE OF PROTEIN AND AMINO ACIDS PROTECT AGAINST HEPATIC IRI REFERENCES 1. Mitchell, J.R., et al., Short-term dietary restriction and fasting precondition against ischemia- reperfusion injury in mice. Aging Cell, 2010. 9(1): p. 40-53. 2. Robertson, L.T. and J.R. Mitchell, Benefits of short-term dietary restriction in mammals. Exp Gerontol, 2013. 48(10): p. 1043-8. 3. Yamagishi, T., et al., Severe, short-term food restriction improves cardiac function following ischemia/reperfusion in perfused rat hearts. Heart Vessels, 2010. 25(5): p. 417-25. 4. McCay, C.M., M.F. Crowell, and L.A. Maynard, The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition, 1989. 5(3): p. 155-71; discussion 172. 5. Mair, W., et al., Demography of dietary restriction and death in Drosophila. Science, 2003. 301(5640): p. 1731-3. 6. Colman, R.J., et al., Caloric restriction delays disease onset and mortality in rhesus monkeys. Science, 2009. 325(5937): p. 201-4. 7. Ravussin, E., et al., A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci, 2015. 70(9): p. 1097-104. 8. Fontana, L., L. Partridge, and V.D. Longo, Extending healthy life span--from yeast to humans. Science, 2010. 328(5976): p. 321-6. 9. Heilbronn, L.K., et al., Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA, 2006. 295(13): p. 1539-48. 10. Verweij, M., et al., Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration. Liver Transpl, 2011. 17(6): p. 695-704. 11. Uemura, T., et al., Liver retransplantation for primary nonfunction: analysis of a 20-year single- center experience. Liver Transpl, 2007. 13(2): p. 227-33. 12. Ben-Ari, Z., et al., Induction of heme oxygenase-1 protects mouse liver from apoptotic ischemia/ reperfusion injury. Apoptosis, 2013. 18(5): p. 547-55. 13. Datta, G., B.J. Fuller, and B.R. Davidson, Molecular mechanisms of liver ischemia-reperfusion injury: insights from transgenic knockout models. World J Gastroenterol, 2013. 19(11): p. 1683- 98. 14. Verweij, M., et al., Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice. Transplantation, 2011. 92(7): p. 752-8. 15. Jensen, K., et al., Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan in Drosophila melanogaster. Aging Cell, 2015. 14(4): p. 605-15. 16. Bruce, K.D., et al., High carbohydrate-low protein consumption maximizes Drosophila lifespan. Exp Gerontol, 2013. 48(10): p. 1129-35.