Franny Jongbloed

138 CHAPTER 5 SUPPLEMENTARY DATA Table S1. List of significantly up-or downregulated upstream transcription factors in the liver by a methionine-free, leucine-free or tryptophane-free diet with the corresponding z-scores Upstream Regulator Gene ratio (Log2) Z-score P- value Z-score P- value Z-score P- value Methionine-free Tryptophan Leucine NFE2L2 0.297 4.545 6.28 E -13 2.975 3.12 E -11 2.919 3.92 E -07 ATF4 0.393 2.911 7.45 E -05 2.686 7.60 E -09 1.838 2.41 E -06 NUPR1 1.593 2.558 8.47 E -04 2.846 2.92 E -05 1.667 1.06 E -05 KMT2D 0.180 2.449 1.15 E -01 N/A N/A N/A N/A CEBPD 0.390 2.194 8.83 E -04 1.994 3.42 E -01 1.104 1.39 E -02 NFKB1 0.007 2.182 1.37 E -01 N/A N/A 0.344 7.05 E -03 KLF4 0.782 2.110 7.47 E -02 1.994 4.08 E -01 3.101 3.00 E -01 SMARCB1 -0.164 2.026 9.12 E -06 2.436 9.74 E -04 2.465 2.14 E -06 TAF4 0.393 2.000 2.57 E -03 N/A N/A N/A N/A MAFF 1.398 2.000 3.37 E -05 N/A N/A N/A N/A TBX2 0.047 -2.000 6.89 E -02 -2.530 7.43 E -04 -1.890 1.11 E -02 Esrra 0.327 -2.000 4.14 E -02 N/A N/A N/A N/A ATF6 0.216 -2.000 7.27 E -03 -0.553 1.78 E -05 -1.161 1.15 E -04 FOXO1 -0.167 -2.139 9.30 E -07 -0.465 1.51 E -09 -1.269 6.53 E -11 STAT5B 0.123 -2.157 2.12 E -02 -0.901 3.17 E -04 -1.463 4.42 E -02 MYBL2 0.157 -2.236 1.79 E -04 -1.633 1.79 E -04 -2.000 1.03 E -02 FOXM1 -0.080 -2.671 1.66 E -04 -3.096 1.76 E -5 -2.391 6.91 E -06 SREBF2 0.086 -2.804 1.26 E -04 -5.540 8.96 E -26 -5.159 1.87 E -28 Leucine-free Tryptophan-free Methionine-free KLF4 0.907 3.101 3.00 E -01 1.994 4.08 E -01 2.110 7.47 E -02 NFE2L2 0.397 2.919 3.92 E -07 2.975 3.12 E -11 4.545 6.28 E -13 KDM5B -0.376 2.739 8.34 E -08 2.999 3.88 E -07 1.615 1.13 E -04 TRIM24 -0.415 2.714 3.19 E -04 3.043 1.20 E -04 N/A N/A SMARCB1 -0.126 2.465 2.14 E -06 2.436 9.74 E -04 2.026 9.12 E -06 POU5F1 -0.120 2.234 4.60 E -01 -1.103 9.75 E -04 N/A N/A ETS1 0.829 2.198 2.28 E -02 N/A N/A N/A N/A NOTCH1 -0.165 2.137 8.04 E -02 0.309 4.59 E -02 0.727 9.18 E -03 MYBL2 0.097 -2.000 1.03 E -02 -1.633 1.79 E -04 -2.236 1.79 E -04 NFYA -0.197 -2.007 1.27 E -11 -0.840 5.51 E -12 -0.128 7.02 E -06 ARNTL 0.217 -2.180 2.56 E -03 -1.539 1.41 E -03 N/A N/A E2F2 -0.287 -2.236 5.13 E -03 N/A N/A N/A N/A PDX1 0.029 -2.321 1.75 E -05 -0.739 6.55 E -06 N/A N/A FOXM1 -0.309 -2.391 6.91 E -06 -3.096 1.76 E -05 -2.671 1.66 E -04