Franny Jongbloed

139 5 ABSENCE OF PROTEIN AND AMINO ACIDS PROTECT AGAINST HEPATIC IRI Table S1. (continued) Upstream Regulator Gene ratio (Log2) Z-score P- value Z-score P- value Z-score P- value E2F1 -0.217 -2.480 1.50 E -05 -1.068 6.08 E -06 -1.564 8.48 E -04 MLXIPL -0.039 -2.510 1.27 E -09 -2.345 1.35 E -07 -0.927 3.18 E -03 IRF7 -0.338 -2.599 2.83 E -01 -3.088 1.15 E -01 N/A N/A SIRT2 0.113 -2.646 8.82 E -07 -2.646 3.30 E -06 N/A N/A PPARGC1B -0.681 -3.396 1.96 E -07 -3.248 1.06 E -05 -1.980 2.81 E -02 SREBF1 -0.534 -4.605 2.68 E -24 -4.998 1.55 E -23 -1.020 6.88 E -05 SREBF2 -0.453 -5.159 1.87 E -28 -5.540 9.96 E -26 -2.804 1.26 E -04 Tryptophan-free Leucine-free Methionine-free TRIM24 0.241 3.043 1.20 E 04 2.714 3.19 E -04 N/A N/A KDM5B -0.602 2.999 3.88 E -07 2.739 8.34 E -08 1.615 1.13 E -04 NFE2L2 0.198 2.975 3.12 E -11 2.919 3.92 E -07 4.545 6.28 E -13 NUPR1 0.772 2.846 2.92 E -05 1.667 1.06 E -05 2.558 8.47 E -04 HTT -0.347 2.784 1.12 E -03 N/A N/A N/A 3.16 E -04 ATF4 0.317 2.686 7.60 E -09 1.838 2.41 E -06 2.911 7.54 E -05 SMARCB1 0.188 2.436 9.74 E -04 2.465 2.14 E -06 2.026 9.12 E -06 HAND2 0.931 2.224 4.42 E -02 N/A N/A N/A N/A FLI1 0.635 2.150 5.36 E -05 1.364 6.55 E -05 N/A N/A FOXO3 -0.209 2.095 2.00 E -10 0.448 9.73 E -08 0.588 1.75 E -06 GATA4 -0.378 2.071 1.12 E -01 N/A N/A N/A N/A TCF3 0.171 2.032 7.48 E -05 1.265 9.72 E -04 1.890 1.66 E -02 IRF5 -0.327 -2.138 5.91 E -03 N/A N/A N/A N/A STAT1 -0.661 -2.145 5.93 E -05 -0.540 1.73 E -06 -1.706 1.34 E -03 MLX -0.124 -2.181 1.20 E -09 -1.977 1.09 E -07 N/A 7.61 E -03 MLXIPL 0.054 -2.345 1.35 E -07 -2.510 1.27 E -09 -0.927 3.18 E -03 MYOD1 0.108 -2.465 1.20 E -01 -1.242 1.85 E -02 -1.657 5.12 E -03 EGR1 -0.180 -2.520 2.14 E -03 -1.925 7.99 E -04 -1.344 3.23 E -02 TBX2 -0.001 -2.530 7.43-04 -1.890 1.11 E -02 -2.000 6.89 E -02 SIRT2 0.170 -2.646 3.30 E -06 -2.646 8.82 E -07 N/A N/A IRF7 -0.349 -3.088 1.15 E -01 -2.599 2.83 E -01 N/A N/A FOXM1 -0.181 -3.096 1.76 E -05 -2.391 6.91 E -06 -2.671 1.66 E -04 IRF3 0.254 -3.128 4.08 E -03 -1.359 5.45 E -04 N/A N/A PPARGC1B -0.755 -3.248 1.06 E -05 -3.396 1.96 E -07 -1.980 2.81 E -02 SREBF1 -0.247 -4.998 1.55 E -23 -4.605 2.68 E -04 -1.020 6.88 E -05 SREBF2 -0.474 -5.540 8.96 E -26 -5.159 1.87 E -28 -2.804 1.26 E -04 All significantly up-or downregulated transcription factors (TF) after completion of each diet are shown, together with then log-ratio of the gene corresponding to the TF. Of all TF, the z-scores of the other two diets are compared and shown in the same table. N/A = not available.