Franny Jongbloed

176 CHAPTER 7 Table 2. Relative changes in metabolic parameters, amino acids and compliance markers after the dietary interventions with their corresponding P- value of intragroup differences Parameter Intervention Restricted Diet (% Change) DER-Diet (% Change) Control (% Change) P- Value Restricted- DER P- Value Restricted- Control P- Value DER- Control Metabolic Albumin (g/L) −9 +7.2 −1.9 0.006 0.212 0.003 Urea (mmol/L) −37.5 +13.8 −2.6 <0.0001 <0.0001 0.067 Creatinine (mmol/L) +15.1 12.2 −2.0 0.51 0.009 0.03 Glucose (mmol/L) −1.8 −0.6 +6.2 0.76 0.10 0.20 Ferritin +17.5 +21.2 +20.2 0.73 0.89 0.95 Insulin (pmol/L) +27.2 +13.7 +52.2 0.70 0.68 0.34 Amino Acids Alanine (mmol/L) −3.6 +3.1 −5.8 0.37 0.74 0.20 Glutamine (mmol/L) +2.1 +0.1 +2.9 0.72 0.90 0.51 Glycine (mmol/L) +7.8 +3.3 +5.0 0.37 0.61 0.73 Histidine (mmol/L) −11.0 −8.6 −0.2 0.72 0.15 0.12 Isoleucine (mmol/L) −12.8 −2.7 +11.0 0.15 0.03 0.15 Leucine (mmol/L) −11.1 +2.1 +8.0 0.01 0.01 0.37 Phenylalanine (mmol/L) −4.9 +5.3 +6.4 0.06 0.03 0.81 Tyrosine (mmol/L) −10.0 +5.0 0.6 0.09 0.19 0.56 Valine (mmol/L) −17.9 +0.7 +11.6 0.002 0.003 0.22 BCAA * (mmol/L) −16.4 −1.3% +8.8% 0.004 0.004 0.22 Miscellaneous Prealbumin (mg/L) −17.2 +1.0 −1.2 0.002 0.0001 0.77 Retinol Binding Protein (mg/L) −20.5 +5.6 −0.9 0.0002 0.0001 0.26 Relative changes in metabolic parameters, amino acids and compliance markers after the dietary interventions with their corresponding p- value of intragroup differences. Values are depicted as mean ± standard error of the mean. Significant p- values are depicted in Italics. Significant p- values after the Bonferroni correction for multiple testing are depicted in bold and Italics. * BCAA = branched chain amino acids; cumulative sum of isoleucine, leucine and valine.