Franny Jongbloed

205 8 BENEFICIAL EFFECTS OF A PREOPERATIVE DIET and eGFR clearance were calculated and analyzed. Again, relative creatinine clearance was significantly improved in the CCPR donors compared to the control group on POD2, POD3 and POMo1 with a difference of 14,6% on average. In addition, relative eGFR was significantly better in the CCPR group as well, both on POD2, POD3 and POMo1 with an improvement difference of 6% on average (Table 2A). Subsequently, changes per time point were assessed. The CCPR donors showed a trend towards better clearance of absolute creatinine compared to the control group (Figure 1A). During the first three postoperative days, relative creatinine clearance was significantly better in the CCPR donors on POD2 ( P= 0.030) and POD3 ( P= 0.042). These values remained significantly different at month 1 after surgery ( P= 0.040, Figure 1B), indicating long-term improvement. Absolute eGFR values did not differ between the groups (Figure 1C). In the first postoperative days, relative eGFR was significantly better in the CCPR donors on POD3 ( P= 0.033) (Figure 1D). Serum urea levels were significantly lower in the CCPR group on POD-1 (P<0.001), suggesting effects of the CCPR diet on kidney function per se. This difference persisted after surgery on POD1 ( P= 0.003), POD2 ( P= 0.005) and lower on POD3 ( P= 0.09) (Figure 1E). Table 2A. Random intercept mixed-effects differences, standard errors (Std. Error) and P- values for kidney function outcome of the living kidney donors Time point Parameter Creatinine (µmol/L) CKD-EPI eGFR (mL/min) Absolute values Difference Std. Error P -value Difference Std. Error P -value POD-pre - 1,83 6,09 0.765 - 6,68 3,66 0.074 POD1 - 6,57 6,09 0.286 - 2,82 3,66 0.445 POD2 - 14,02 6,13 0.027 + 0,38 3,67 0.918 POD3 - 15,35 6,29 0.018 + 1,22 3,78 0.748 POMo1 - 14,52 6,19 0.023 + 1,73 3,70 0.643 POMo3 - 10,23 6,13 0.102 - 1,42 3,68 0.701 Relative values Difference Std. Error P -value Difference Std. Error P -value POD1 - 4,38 72,44 0.399 + 1,30 2,34 0.579 POD2 - 13,95 76,15 0.010 + 5,36 2,38 0.027 POD3 - 15,53 88,28 0.006 + 5,78 2,51 0.024 POMo1 - 14,35 80,27 0.009 + 7,14 2,42 0.004 POMo3 - 9,28 77,61 0.084 + 3,04 2,39 0.208