Franny Jongbloed

227 8 BENEFICIAL EFFECTS OF A PREOPERATIVE DIET POD-pre POD-1 POD1 POD2 POD3 POMo1 POMo3 0 25 50 75 100 125 150 CCPR (n=4) Control (n=13) * Time after donation Creatinine (mmol/L) POD-pre POD-1 POD1 POD2 POD3 POMo1 POMo3 0 25 50 75 100 125 150 175 200 CCPR (n=4) Control (n=13) * Time after donation Relative creatinine (%) POD-pre POD-1 POD1 POD2 POD3 POMo1 POMo3 0 20 40 60 80 100 CCPR (n=4) Control (n=13) Time after donation CKD-EPI eGFR (mL/min) POD-pre POD-1 POD1 POD2 POD3 POMo1 POMo3 0 25 50 75 100 125 CCPR (n=4) Control (n=13) Time after donation Relative CKD-EPI eGFR (%) POD-1 POD1 POD2 POD3 POD4 POD5 POD6 POD7 POD14 POD21 POMo1 POMo2 POMo3 POMo6 0 200 400 600 800 1000 CCPR (n=4) Control (n=13) Time after transplantation Creatinine (mmol/L) POD-1 POD1 POD2 POD3 POD4 POD5 POD6 POD7 POD14 POD21 POMo1 POMo2 POMo3 POMo6 0 20 40 60 80 100 CCPR (n=4) Control (n=13) Time after transplantation Relative creatinine (%) POD-1 POD1 POD2 POD3 POD4 POD5 POD6 POD7 POD14 POD21 POMo1 POMo2 POMo3 POMo6 0 20 40 60 80 CCPR (n=4) Control (n=13) Time after transplantation CKD-EPI eGFR (mL/min) POD-1 POD1 POD2 POD3 POD4 POD5 POD6 POD7 POD14 POD21 POMo1 POMo2 POMo3 POMo6 0 200 400 600 800 1000 CCPR (n=4) Control (n=13) Time after transplantation Relative CKD-EPI eGFR (%) A B C D E F G H Figure S4. Kidney function of male living kidney donors before and after live kidney donation. (A) Absolute levels of serum creatinine of the male kidney donors were significantly higher prior to start of the CCPR diet, while no differences between the two intervention groups were seen postoperatively. (B) Relative creatinine levels were significantly improved in the CCPR diet on postoperative month (POMo)1. (C) Estimated glomerular filtration rate (eGFR) showed a lower eGFR in the CCPR prior to start intervention and no differences postoperatively, with similar changes (D) in relative eGFR levels. In the kidney transplant recipients of male kidney donors, (E) absolute creatinine levels were improved as from POD1 until POD7, while (F) relative creatinine levels were better as from POD3 until POD14. (G) Absolute eGFR and the (H) relative eGFR showed a trend towards improvement postoperatively. Values are depicted as median ± interquartile range. CCPR = combined calorie and protein restriction; POD = postoperative day; POMo = postoperative month; eGFR = estimated glomerular filtration rate. *= P< 0.05.