Franny Jongbloed

232 CHAPTER 8 Table S3. Pathway and upstream transcription factor analysis in renal tissue of male donors Ingenuity Canonical Pathways Ratio Up/Down P- value Z-score Xenobiotic Metabolism Signaling 10/287 (3.5%) 4/6 4.80 E -06 N/A Antigen Presentation Pathway 4/38 (10.5%) 1/3 5.83 E -05 N/A Serotonin Degradation 5/75 (6.7%) 0/5 6.23 E -05 N/A LPS/IL-1-Mediated Inhibition of RXR Function 7/221 (3.2%) 2/5 2.42 E -04 N/A Nicotine Degradation II 4/63 (6.3%) 1/3 4.23 E -04 N/A Superpathway of Melatonin Degradation 4/68 (5.9%) 0/4 5.66 E -04 N/A Allograft Rejection Signaling 4/84 (4.8%) 1/3 1.25 E -03 N/A Thyroid Hormone Metabolism II 3/41 (7.3%) 0/3 1.54 E -03 N/A OX40 Signaling Pathway 4/91 (4.4%) 1/3 1.68 E -03 N/A Autoimmune Thyroid Disease Signaling 3/47 (6.4%) 1/2 2.28 E -03 N/A Graft-versus-Host Disease Signaling 3/48 (6.2%) 1/2 2.43 E -03 N/A Phenylalanine Degradation IV 2/14 (14.3%) 0/2 2.68 E -03 N/A Nicotine Degradation III 3/54 (5.6%) 0/3 3.40 E -03 N/A Type I Diabetes Mellitus Signaling 4/111 (3.6%) 2/2 3.46 E -03 N/A Melatonin Degradation I 3/63 (4.8%) 0/3 5.25 E -03 N/A The top 15 overrepresented pathways derived from the differentially expressed transcripts (DET) in the CCPR diet compared to the control group in kidney biopsies of male donors. The pathways show their corresponding ratio of regulated genes as percentage of total genes in the pathway, the P- value and the Z-score for predicted activation of inhibition of the pathways.