Franny Jongbloed

233 8 BENEFICIAL EFFECTS OF A PREOPERATIVE DIET Table 3. (continued) Upstream regulator Description Z-score P- value Gene log ratio KLF4 Kruppel like factor 4 +2.198 7.17 E -04 -0.304 NUPR1 Nuclear protein 1, transcription regulator +2.000 3.39 E -01 +0.081 RELA RELA proto-oncogene, NF-κB subunit +1.970 2.53 E -03 -0.513 KLF5 Kruppel like factor 5 +1.957 2.78 E -04 +0.803 CCND1 Cyclin D1 +1.387 1.37 E -02 +0.294 JUN Jun proto-oncogene, AP-1 transcription factor subunit +1.296 4.75 E -02 -0.129 HIF1A Hypoxia inducible factor 1 alpha subunit +1.250 5.40 E -04 +0.763 MYC MYCN proto-oncogene, bHLH transcription factor +1.224 1.97 E -04 +0.537 NOTCH1 Notch 1 +1.188 1.49 E -02 +0.357 TWIST1 Twist family bHLH transcription factor 1 +1.000 2.04 E -03 -0.152 TP73 Tumor protein 73 +0.639 7.73 E - 04 +0.170 NKX2-3 NK2 homeobox 3 +0.447 9.09 E -03 +0.039 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 +0.378 2.59 E -02 -0.350 NFKBIA NFκB inhibitor alpha +0.295 4.07 E -03 +0.163 GATA3 GATA binding protein 3 +0.152 3.62 E -02 -0.181 TP53 Tumor protein 53 +0.128 1.99 E -06 -0.259 TP63 Tumor protein 63 +0.101 7.14 E -03 +0.116 SP1 Sp1 transcription factor -0.063 1.50 E -03 -0.240 ATF3 Activating transcription factor 3 -0.106 1.8e E -03 -0.182 NFE2L2 Nuclear factor, erythyroid 2 like 2 -0.562 3.28 E -02 +0.331 CEBPA CCAAT/enhancer binding protein alpha -0.727 3.54 E -03 +0.441 MYCN MYCN proto-oncogene, bHLH transcription factor -0.923 2.36 E -02 -0.030 HMGA1 High mobility group AT-hook 1 -1.000 1.13 E -02 +0.945 CREBBP CREB binding protein -1.004 8.07 E -03 +0.409 KLF3 Kruppel like factor 3 -1.134 3.35 E -03 -0.302 CEBPB CCAAT/enhancer binding protein beta -1.353 2.65 E -03 -0.186 HNF4A Hepatocyte nuclear factor 4 alpha -3.331 7.37 E -04 -0.470 Differentially regulated upstream transcription factors (TFs) derived from the DET in the CCPR diet compared to the control group in kidney biopsies of male donors, with their corresponding Z-score and gene log ratio. Significantly activated or inhibited TFs are depicted in bold.