Franny Jongbloed

253 9 SUMMARY AND DISCUSSION In overall conclusion, in this thesis we provide new evidence that various short-term dietary restriction interventions are able to induce beneficial effects on acute-stress related injury in various mouse models, human living kidney donors and their transplant recipients, and substantiated these results with promising new insights into the molecular mechanisms using gene expression analyses. We are only a few steps away from the successful application of nutritional precondition in elective surgery. Future studies should finalize these steps by validating the clinical results in larger and different patient cohorts as well as provide posttranscriptional mechanisms underlying dietary restriction. These data should bring us to the optimal preoperative nutritional regimen, either via dietary restriction or a dietary restriction mimetic, to implement in standard care for elective surgery patients.