Franny Jongbloed

255 9 SUMMARY AND DISCUSSION 20. Cangemi, A., et al. Dietary restriction: could it be considered as speed bump on tumor progression road? Tumour Biol 37, 7109-7118 (2016). 21. Turturro, A., Hass, B.S. & Hart, R.W. Does caloric restriction induce hormesis? Hum Exp Toxicol 19, 320-329 (2000). 22. Masoro, E.J. Caloric restriction and aging: controversial issues. J Gerontol A Biol Sci Med Sci 61, 14-19 (2006). 23. Cavallini, G., Donati, A., Gori, Z. & Bergamini, E. Towards an understanding of the anti-aging mechanism of caloric restriction. Curr Aging Sci 1, 4-9 (2008). 24. Hine, C.M. & Mitchell, J.R. NRF2 and the Phase II Response in Acute Stress Resistance Induced by Dietary Restriction. J Clin Exp Pathol S4(2012). 25. Yuan, M., Pino, E., Wu, L., Kacergis, M. & Soukas, A.A. Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem 287, 29579-29588 (2012). 26. Pearson, K.J., et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A 105, 2325-2330 (2008). 27. Geissler, E.K. & Schlitt, H.J. The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation. Kidney Int 78, 1075-1079 (2010). 28. Esposito, C., et al. Sirolimus prevents short-term renal changes induced by ischemia-reperfusion injury in rats. Am J Nephrol 33, 239-249 (2011). 29. Zhang, C., et al. Rapamycin protects kidney against ischemia-reperfusion injury through recruitment of NKT-cells. J Transl Med 12, 224 (2014). 30. Hirota, K., et al. Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor. J Biol Chem 278, 13056-13060 (2003). 31. Daemen, S., Kutmon, M. & Evelo, C.T. A pathway approach to investigate the function and regulation of SREBPs. Genes Nutr 8, 289-300 (2013). 32. van den Berg, M.C. & Burgering, B.M. Integrating opposing signals toward Forkhead box O. Antioxid Redox Signal 14, 607-621 (2011). 33. Fusco, S. & Pani, G. Brain response to calorie restriction. Cell Mol Life Sci 70, 3157-3170 (2013). 34. Obrochta, K.M., Krois, C.R., Campos, B. & Napoli, J.L. Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1. J Biol Chem 290, 7259-7268 (2015). 35. Lageix, S., Rothenburg, S., Dever, T.E. & Hinnebusch, A.G. Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2alpha phosphorylation in starved cells. PLoS Genet 10, e1004326 (2014). 36. Harputlugil, E., et al. The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo. Cell Rep 8, 1160-1170 (2014). 37. Kalimuthu, S.N. & Chetty, R. Gene of the month: SMARCB1. J Clin Pathol 69, 484-489 (2016). 38. Shanley, D.P. & Kirkwood, T.B. Calorie restriction and aging: a life-history analysis. Evolution 54, 740-750 (2000).