Franny Jongbloed

45 2 FASTING PROTECTS AGED-OVERWEIGHT MICE Table S3. Top genes upregulated in young mice fasted for three days Genes YOUNG upregulated Symbol Log FR P- value 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) HMGCS2 5.227 1.69 E -07 cytochrome P450, family 4, subfamily a, polypeptide 14 Cyp4a14 4.842 9.85 E -07 carbonyl reductase 3 CBR3 3.565 4.18 E -08 aldehyde dehydrogenase 1 family, member A1 ALDH1A1 3.307 5.82 E -09 pyruvate dehydrogenase kinase, isozyme 4 PDK4 3.071 4.25 E -07 cell death-inducing DFFA-like effector a CIDEA 2.841 2.45 E -02 receptor accessory protein 6 REEP6 2.757 2.82 E -07 aldehyde dehydrogenase family 1, subfamily A7 Aldh1a7 2.625 2.57 E -07 phosphoenolpyruvate carboxykinase 1 (soluble) PCK1 2.608 5.70 E -05 acyl-CoA thioesterase 1 ACOT1 2.590 8.71 E -07 arbonyl reductase 1 CBR1 2.573 8.78 E -08 nuclear factor, erythroid 2-like 2 NFE2L2 2.573 2.00 E -07 cytochrome P450, family 2, subfamily d, polypeptide 22 Cyp2d22 2.531 1.21 E -07 fibrinogen gamma chain FGG 2.508 2.66 E -06 solute carrier family 25, member 25 SLC25A25 2.507 5.74 E -06 atonal homolog 7 (Drosophila) ATOH7 2.478 3.35 E -08 solute carrier family 38, member 3 SLC38A3 2.456 4.25 E -07 group-specific component (vitamin D binding protein) GC 2.437 5.65 E -06 monoamine oxidase B MAOB 2.363 1.67 E -05 mitochondrial amidoxime reducing component 1 MARC1 2.270 1.94 E -05 arginase 2 ARG2 2.180 3.60 E -06 complement component 3 C3 2.176 9.85 E -07 glutathione S-transferase alpha 5 GSTA5 2.166 3.73 E -05 fibrinogen alpha chain FGA 2.086 2.12 E -05 lectin, galactoside-binding, soluble, 4 LGALS4 2.051 5.67 E -06 insulin-like growth factor binding protein 1 IGFBP1 2.035 1.03 E -03 CCR4 carbon catabolite repression 4-like (S. cerevisiae) CCRN4L 2.006 8.54 E -05 perilipin 5 PLIN5 1.981 1.05 E -06 abhydrolase domain containing 15 ABHD15 1.964 3.11 E -07 paternally expressed 3 PEG3 1.947 1.97 E -05 retinol dehydrogenase 1 (all trans) Rdh1 1.916 4.25 E -07 early growth response 1 EGR1 1.901 2.54 E -02 pyridoxal (pyridoxine, vitamin B6) kinase PDXK 1.894 1.15 E -05 betaine--homocysteine S-methyltransferase BHMT 1.886 4.91 E -03