Franny Jongbloed

47 2 FASTING PROTECTS AGED-OVERWEIGHT MICE Table S4. Top genes downregulated in young mice fasted for three days Genes YOUNG downregulated Symbol Log FR P- value Solute carrier family 22, member 7 SLC22A7 -3.713 8.28 E -08 Kinesin family member 20B KIF20B -3.379 4.11 E -06 Hydroxy-delta-5-steroid dehydrogenase 3, beta- and steroid-isomerase 1 HSD3B1 -2.950 1.04 E -06 Branched chain amino-acid transaminase 1 BCAT1 -2.838 1.94 E -05 Histone cluster 2, H3c HIST2H3C -2.818 5.05 E -07 major facilitator superfamily domain containing 2A MFSD2A -2.756 1.27 E -04 isopentenyl-diphosphate delta isomerase 1 IDI1 -2.712 2.96 E -08 solute carrier family 9, subfamily A, member 8 SLC9A8 -2.679 1.07 E -07 gamma-aminobutyric acid (GABA) A receptor, beta 3 GABRB3 -2.502 1.25 E -05 solute carrier family 7, member 13 SLC7A13 -2.418 3.09 E -02 heat shock transcription factor 2 binding protein HSF2BP -2.337 7.43 E -07 myosin VA (heavy chain 12, myoxin) MYO5A -2.334 5.95 E -06 synapsin III SYN3 -2.324 4.15 E -06 collagen, type III, alpha 1 COL3A1 -2.229 1.05 E -06 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 ST8SIA1 -2.212 7.42 E -07 chemokine ligand 9 CXCL9 -2.184 1.17 E -04 ornithine decarboxylase 1 ODC1 -2.106 4.25 E -07 cytochrome P450, family 51, subfamily A, polypeptide 1 CYP51A1 -2.088 2.82 E -07 family with sequence similarity 151, member A FAM151A -2.018 5.95 E -06 GRB10 interacting GYF protein 2 GIGYF2 -1.968 6.45 E -06 aldo-keto reductase family 1, member C3 AKR1C3 -1.943 1.11 E -04 C1q and tumor necrosis factor related protein 3 C1QTNF3 -1.943 1.60 E -06 midkine (neurite growth-promoting factor 2) MDK -1.937 6.72 E -05 kinesin family member 12 KIF12 -1.928 8.78 E -08 SLIT and NTRK-like family, member 6 SLITRK6 -1.890 9.74 E -05 McKusick-Kaufman syndrome MKKS -1.843 2.30 E -05 3-hydroxy-3-methylglutaryl-CoA reductase HMGCR -1.838 7.06 E -06 solute carrier family 35, member F1 SLC35F1 -1.809 6.67 E -07 solute carrier family 34, member 3 SLC34A3 -1.782 3.50 E -05 C-type lectin domain family 2, member h Clec2h -1.780 7.84 E -05 guanylate binding protein 6 Gbp6 -1.778 1.10 E -04 solute carrier family 8, member 1 SLC8A1 -1.770 6.25 E -06 UDP-Gal:beta GlcNAc beta 1,4- galactosyltransferase, polypeptide 5 B4GALT5 -1.755 6.58 E -07 protein Z, vitamin K-dependent plasma glycoprotein PROZ -1.745 9.18 E -07