Franny Jongbloed

57 3 PROTECTION OF FASTING ON IRINOTECAN TOXICITY (A) (B) (C) (D) AL Vehicle AL irinotecan Fasting irinotecan 2667 LIVER Fasting Vehicle 754 Figure 2. (A) Unbiased principal component analyses (PCA) of liver samples, based on all probe sets in the microarray. Principal component (PC) 1 is depicted on the x-axis and PC2 is depicted on the y-axis, including the percentage of variance explained by each PC. Each symbol represents one sample of one mouse. Samples of the same group are shown in the same color. AL = ad libitum. (B) Number of significantly differentially expressed probe sets (DEPS) in livers of AL and fasted mice. (C) Venn diagram of overlapping DEPS due to irinotecan exposure in AL and fasted mice. (D) Scatterplot of probe set fold expression changes with false discovery rates of 5% or less after irinotecan administration in liver of either AL fed mice (x-axis) or fasted mice (y-axis). Red symbols = AL groups; green symbols = fasting groups; black symbols = overlapping DEPS.