Franny Jongbloed

58 CHAPTER 3 Table 1. Overview of the top overrepresented canonical pathways in liver ranked by their P- value Canonical Pathway Pathway classification P- value Genes Ratio Z-score Liver – AL vehicle vs. AL irinotecan Signaling by Rho Family GTPases Intracellular and second messenger signaling 4.99 E -03 34/248 (13.7%) +3.128 LPS/IL-1 Mediated Inhibition of RXR Function Nuclear Receptor Signaling 2.74 E -03 32/221 (14.5%) +2.840 RhoA Signaling Intracellular and second messenger signaling 1.02 E -02 19/124 (15.3%) +2.668 EIF2 Signaling Intracellular and second messenger signaling; cellular stress and injury; cellular growth and proliferation and development 9.16 E -03 30/221 (13.6%) +2.500 Role of NFAT in Cardiac Hypertrophy Cardiovascular Signaling 4.72 E -03 28/193 (14.5%) +2.000 Ephrin Receptor Signaling Organismal growth and development; neurotransmitter and other nervous system signaling 2.12 E -03 27/174 (15.5%) +1.789 Sumoylation Pathway Cellular stress and injury; cellular growth and proliferation and development 1.36 E -03 18/96 (18.8%) +1.604 IL-1 signaling Cytokine Signaling 5.31 E -03 16/92 (17.4%) +1.604 Integrin Signaling Cell cycle regulation; intracellular and second messenger signaling; cellular growth and proliferation and development 8.08 E -03 30/219 (13.7%) +1.512 Remodeling of Epithelial Adherens Junctions Cellular growth and proliferation and development 3.40 E -02 11/69 (15.9%) +1.414 LPS-stimulated MAPK Signaling Apoptosis 3.61 E -02 13/87 (14.9%) +1.387 fMLP Signaling in Neutrophils Cytokine signaling; cellular immune response 1.25 E -04 24/123 (19.5%) +1.279 NRF2-mediated Oxidative Stress Response Cellular stress and injury 4.55 E -02 24/193 (12.4%) +1.291 IL-8 Signaling Cytokines signaling; cellular immune response 3.34 E -05 35/197 (17.8%) +1.219 Sphingosine-1-phosphate Signaling Organismal growth and development 2.20 E -02 18/125 (14.4%) +1.213 CXCR4 Signaling Cytokine signaling; cellular immune response 7.63 E -05 30/165 (18.2%) +1.177 Phospholipase C Signaling Intracellular and second messenger signaling 9.43 E -03 32/240 (13.3%) +1.000 Calcium-induced T Lymphocyte Apoptosis Apoptosis; cellular immune response 3.87 E -03 13/66 (19.7%) -1.732 Huntington’s Disease Signaling Neurotransmitter and other nervous system signaling 3.06 E -02 30/243 (12.3%) -1.606 eNOS Signaling Cardiovascular Signaling 1.25 E -03 27/168 (16.1%) -1.091