Franny Jongbloed

59 3 PROTECTION OF FASTING ON IRINOTECAN TOXICITY Table 1. (continued) Canonical Pathway Pathway classification P- value Genes Ratio Z-score Liver – Fasting vehicle vs. Fasting irinotecan RhoGDI Signaling Intracellular and second messenger signaling 5.03 E -03 11/173 (6.4%) +2.333 Toll-like Receptor Signaling Apoptosis; humoral/cellular immune response 4.50 E -02 5/76 (6.6%) +1.342 NRF2-mediated Oxidative Stress Response Cellular stress and injury 4.63 E -04 14/193 (7.3%) +1.000 PTEN Signaling Apoptosis; cancer 3.51 E -03 9/119 (7.6%) +1.000 Dopamine-DARPP32 Feedback in cAMP Signaling Intracellular and second messenger signaling; neurotransmitter and other nervous system signaling 2.45 E -02 9/163 (5.5%) -2.121 Aryl Hydrocarbon Receptor Signaling Cell cycle regulation; apoptosis; xenobiotic metabolism; nuclear receptor signaling 2.76 E -02 8/140 (5.7%) -2.121 GNRH Signaling Neurotransmitters and other nervous system signaling 1.19 E -04 12/129 (9.3%) -1.732 Huntington’s Disease Signaling Neurotransmitter and other nervous system signaling 1.00 E -02 13/243 (5.3%) -1.732 Synaptic Long Term Potentiation Neurotransmitter and other nervous system signaling 3.92 E -03 9/121 (7.4%) -1.667 Chemokine Signaling Cytokine signaling; organismal growth and development 9.55 E -03 6/71 (8.5%) -1.633 Sperm Motility Organismal growth and development 4.47 E -02 7/127 (5.5%) -1.633 Cardiac Hypertrophy Signaling Cardiovascular signaling 1.16 E -03 15.236 (6.4%) -1.604 Signaling by Rho Family GTPases Intracellular and second messenger signaling 6.85 E -04 16/248 (6.5%) -1.508 Leukocyte Extravasation Signaling Cellular Immune response 2.02 E -02 11/211 (5.2%) -1.508 Colorectal Cancer Metastasis Signaling Cancer 2.63 E -02 12/248 (4.8%) -1.508 eNOS Signaling Cardiovascular Signaling 1.13 E -02 10/168 (6.0%) -1.414 STAT3 Pathway Cellular growth and proliferation and development 4.09 E -02 5/74 (6.8%) -1.342 Thrombin Signaling Cardiovascular signalling 2.54 E -04 15/204 (7.4%) -1.291 Glioma Signaling Cancer 1.40 E -04 11/112 (9.8%) -1.265 Renin-Angiotensin Signaling Cardiovascular signaling; growth factor signaling 1.17 E -03 10/122 (8.2%) -1.265 fMLP Signaling in Neutrophils Cytokine signaling; cellular immune response 1.24 E -03 10/123 (8.1%) -1.265 Tec Kinase Signaling Intracellular and second messenger signaling 1.46 E -03 12/170 (7.1%) -1.265 P2Y Purigenic Receptor Signaling Pathway Cardiovascular signaling 2.23 E -03 10/133 (7.5%) -1.265 Glioblastoma Multiforme Signaling Cancer 8.21 E -03 10/160 )6.2%) -1.265 Dendritic Cell Maturation Cytokines signaling; cellular immune response 1.07 E -02 11/192 (5.7%) -1.265 IL-8 Signaling Cytokines signaling; cellular immune response 1.33 E -05 17/197 (8.6%) -1.213