Franny Jongbloed

76 CHAPTER 3 Figure S2. Overview of the pathway of irinotecan and its metabolism outside and inside the liver cell, including the transportation into the intestine. The main genes and transporters known to be involved in the pathway are depicted. Ces = carboxylesterase; SN-38= active metabolite of irinotecan; SN-38G = SN-38 glucuronide form; Abcc = ATP binding cassette subfamily C; NPC/APC = carbonyloxycamptothecin; Cyp3a = cytochrome P450 3A; Ugt1a1 = Uridine glucuronosyltransferase 1A1.