Marilen Benner

CHAPTER 6 160 Table 2. Pattern recognition receptor expression on endometrial cells Pattern recognition receptor Expressed on EEC ESC Cyclical changes Pathogen-associated molecular pattern Pathogen Reference Toll-like receptor TLR1 Plasma membrane x (x) - Lipid-containing PAMPs e.g. LTA Gram pos. bacteria, fungi, Aflatoonian et al., 2007, Young et al., 2004 (together with TLR2/6) TLR2 Plasma membrane x x x Lipid-containing PAMPs e.g. LTA (together with TLR2/6), zymosan Gram pos. bacteria, fungi Aflatoonian et al., 2007, Hirata et al., 2007, Young et al., 2004 TLR6 Plasma membrane x (x) x See TLR1/2 Aflatoonian et al., 2007 TLR4 Plasma membrane x x x LPS, LipidA Gram neg. bacteria Aflatoonian et al., 2007, Hirata et al., 2007, Young et al., 2004 TLR5 Plasma membrane x (x) x Flagellin Flagellated bacteria Aflatoonian et al., 2007, Young et al., 2004 TLR3 Endosome x x x dsRNA Virus Aflatoonian et al., 2007, Hirata et al., 2007, Jorgensen et al., 2005, Schaefer et al., 2005 Young et al., 2004, TLR7 Endosome x x - ssRNA Virus, bacteria Aflatoonian et al., 2007 TLR8 Endosome x x - ssRNA Virus, bacteria Aflatoonian et al., 2007 TLR9 Endosome x x x CpG-rich unmethylated ssDNA Virus, bacteria Aflatoonian et al., 2007, Hirata et al., 2007, Young et al., 2004 TLR10 Endosome x x x Unknown Aflatoonian et al., 2007 Nod-like receptor Nod1 Cytoplasm x low - Peptidoglycan (gram pos. bacteria cell wall component) Gram pos./neg. Bacteria Ghosh et al., 2013, King et al., 2009 Nod2 Cytoplasm x x x Muramyl dipeptide Gram pos./neg. Bacteria Ghosh et al., 2013, King et al., 2009 Inflammasome Cytoplasm x low nd Muramyl dipeptide Gram pos./neg. Bacteria D’Ippolito et al., 2016