Marilen Benner

GRAPHICAL SUMMARY 247 9 CHAPTER 2 | HUMAN UTERINE LYMPHOCYTES ACQUIRE A MORE EXPERIENCED AND TOLEROGENIC PHENOTYPE DURING PREGNANCY 12ml 6ml M e n s t r u a l c u p ? ?% Memory Tolerance Naive * *altered receptor expression? ?% Decidua parietalis Aim: Results & Conclusions: Immune changes through pregnancy Maternal Fetal Post-pregnancy mucosa Post-pregnancy mucosa ?% ?% How does the uterine immune environment change during pregnancy? • Decreased abundance of naïve T cells in decidua parietalis. • Increase in central/effector memory T cells. • More regulatory T cells at the end of pregnancy. • Mucosal cells differ in phenotype from peripheral blood.