Marilen Benner

CHAPTER 9 250 CHAPTER 5 | A COMBINATION OF IMMUNE CELL TYPES, IDENTIFIED THROUGH AN ENSEMBLE MACHINE LEARNING STRATEGY, DETECTS ALTERED PROFILE IN RECURRENT PREGNANCY LOSS Recurrent pregnancy loss Uncomplicated pregnancies Immune pro ling Systemic&uterine immune cell subsets allowclassi cation Di erences in immune pro le in recurrent pregnancy loss? Machine learningensemble recursive feature selection 1 2 • Altered immune profiles in women who experienced recurrent pregnancy loss. • Systemic and uterine immunity are both affected but different cell types contribute to classification. • High accuracy → possible diagnostic value upon further validation.