Marilen Benner

CONTENTS Chapter 1 General introduction Part I Local immune regulation Chapter 2 Human uterine lymphocytes acquire a more experienced and tolerogenic phenotype during pregnancy (Scientific reports, 2017) Chapter 3 Three types of functional regulatory T cells control T cell responses at the human maternal-fetal interface (Cell Reports, 2019) Chapter 4 Clusters of tolerogenic B cells feature in the dynamic immunological landscape of the pregnant uterus (Cell Reports, 2020) Chapter 5 A combination of immune cell types, identified through an ensemble machine learning strategy, detects altered profile in recurrent pregnancy loss Part II Microbial contribution to reproductive health Chapter 6 How uterine microbiota might be responsible for a receptive, fertile endometrium (Human Reproduction Update, 2018) Chapter 7 Antibiotic intervention affects maternal immunity during gestation in mice Part III Connecting the pieces Chapter 8 Summary and Discussion Chapter 9 Graphical summary Chapter 10 Samenvatting (Dutch summary) Chapter 11 Zusammenfassung (German summary) Chapter 12 Afterword Part IV Appendix Chapter 13 FAIR principles Acknowledgements – Dankwoord - Danksagung Curriculum Vitae RIMLS PhD portfolio List of publications 09 23 25 51 83 109 135 137 187 215 217 243 255 265 275 279 283 285 291 293 297