Marilen Benner

THREE TYPES OF TREG CONTROL PLACENTAL INFLAMMATION 71 3 REFERENCES 1. Erlebacher A. Immunology of the Maternal-Fetal Interface. Annu Rev Immunol. 2013;31(1):387-411. 2. Tilburgs T, Roelen DL, van der Mast BJ, de Groot-Swings GM, Kleijburg C, Scherjon SA, et al. Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy. Journal of immunology (Baltimore, Md : 1950). 2008;180(8):5737-45. 3. Tilburgs T, Scherjon SA, van der Mast BJ, Haasnoot GW, Voort-Maarschalk MV-v, Roelen DL, et al. Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells. Journal of reproductive immunology. 2009;82(2):148-57. 4. Du MR, Guo PF, Piao HL, Wang SC, Sun C, Jin LP, et al. Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells. Journal of immunology (Baltimore, Md : 1950). 2014;192(4):1502-11. 5. Svensson-Arvelund J, Mehta RB, Lindau R, Mirrasekhian E, Rodriguez-Martinez H, Berg G, et al. The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages. Journal of immunology (Baltimore, Md : 1950). 2015;194(4):1534-44. 6. Tilburgs T, Crespo ÂC, van der Zwan A, Rybalov B, Raj T, Stranger B, et al. Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes. Proc Natl Acad Sci USA. 2015;112(23):7219-24. 7. Meuleman T, van Beelen E, Kaaja RJ, van Lith JM, Claas FH, Bloemenkamp KW. HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriage. Journal of reproductive immunology. 2016;116:28-34. 8. Kisielewicz A, Schaier M, Schmitt E, Hug F, Haensch GM, Meuer S, et al. A distinct subset of HLA-DR+- regulatory T cells is involved in the induction of preterm labor during pregnancy and in the induction of organ rejection after transplantation. Clin Immunol. 2010;137(2):209-20. 9. Koucky M, Malickova K, Cindrova-Davies T, Germanova A, Parizek A, Kalousova M, et al. Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor. Journal of reproductive immunology. 2014;106:110-7. 10. Schober L, Radnai D, Schmitt E, Mahnke K, Sohn C, Steinborn A. Term and preterm labor: decreased suppressive activity and changes in composition of the regulatory T-cell pool. Immunol Cell Biol. 2012;90(10):935-44. 11. Steinborn A, Haensch GM, Mahnke K, Schmitt E, Toermer A, Meuer S, et al. Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia? Clin Immunol. 2008;129(3):401-12. 12. Wagner MI, Jost M, Spratte J, Schaier M, Mahnke K, Meuer S, et al. Differentiation of ICOS+ and ICOS- recent thymic emigrant regulatory T cells (RTE T regs) during normal pregnancy, pre-eclampsia and HELLP syndrome. Clin Exp Immunol. 2016;183(1):129-42. 13. Inada K, Shima T, Nakashima A, Aoki K, Ito M, Saito S. Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content. Journal of reproductive immunology. 2013;97(1):104-11.

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