PET/CT response after induction chemotherapy 129 CHAPTER 7 CMR PMR NR P-value Sens Spec Sens Spec Sens Spec 42 percent 87 percent 53 percent 51 percent 37 percent 77 percent 0.010 39 percent 88 percent 65 percent 57 percent 44 percent 59 percent 0.030 50 percent 86 percent 25 percent 35 percent 22 percent 70 percent 0.018 37 percent 89 percent 50 percent 44 percent 38 percent 77 percent 0.070 47 percent 85 percent 58 percent 58 percent 36 percent 78 percent 0.175 40 percent 87 percent 50 percent 48 percent 29 percent 73 percent 0.079 57 percent 87 percent 67 percent 62 percent 67 percent 94 percent 0.016 42 percent 87 percent 51 percent 50 percent 36 percent 77 percent 0.012 33 percent 88 percent 67 percent 60 percent 50 percent 78 percent 0.766 41 percent 88 percent 50 percent 50 percent 32 percent 75 percent 0.024 50 percent 86 percent 67 percent 57 percent 60 percent 91 percent 0.192 50 percent 88 percent 59 percent 51 percent 38 percent 83 percent 0.003 25 percent 85 percent 43 percent 50 percent 33 percent 65 percent 0.725 29 percent 90 percent 68 percent 45 percent 42 percent 83 percent 0.214 53 percent 85 percent 42 percent 56 percent 33 percent 72 percent 0.033 57 percent 78 percent 33 percent 55 percent 25 percent 81 percent 0.033 23 percent 92 percent 60 percent 50 percent 55 percent 74 percent 0.283 56 percent 74 percent 47 percent 62 percent 30 percent 74 percent 0.364 31 percent 95 percent 57 percent 48 percent 50 percent 72 percent 0.086 40 percent 97 percent 64 percent 48 percent 42 percent 75 percent 0.009 43 percent 76 percent 39 percent 53 percent 33 percent 79 percent 0.363 ASA, AmericanSocietyof Anesthesiologists; CMR, completemetabolic response; PET, positronemission tomography; NR, no response, PMR, partial metabolic response; Sens, sensitivity, Spec, specificity. Figure 4 shows the correlation between the PET/CT outcomes and histopathological responses dividedby long and short intervals. Thediscriminationbetweenpatientswith amajor histopathological responseand thosewhohadapartial or poor histopathological response is better when surgery is performed within 51 days (positive predictive value for a major histopathological response is 86 percent, compared to 53 percent after a long interval).
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